1990
서울대학교 치과대학 치의학과 학사
1992
서울대학교 대학원 치의학과 석사
1996
서울대학교 대학원 치의학과 박사
1993. 01.–1995. 02
Visiting Researcher, School of Dentistry, UCLA, USA
1997. 03.–현재
서울대학교 치과대학/치의학대학원 전임강사, 조교수, 부교수, 교수
2015. 01.–2016. 12.
서울대학교 치의학대학원 연구부원장 및 치의학과장
2019. 02.–2020. 12.
서울대학교 치학연구소장
2015. 04.–2017. 03.
한국연구재단 의약학단 전문위원
2003. 03.–2007. 12.
대한구강생물학회 기획홍보이사, 편집이사, 총무이사
2016. 06.–현재
대한골대사학회 연구이사, 구강악안면연구이사, 부회장
치주염과 같은 염증성 질환, 당뇨, 노화 등에 수반되는 뼈 소실에 관여하는 세포생물학적 기전을 규명하고, 뼈 소실의 완화 또는 뼈 재생을 촉진하는 효능을 가진 천연물의 스크리닝 및 작용기전 탐색에 대한 연구를 주로 수행하고 있음.
1997. 05.
대한치과의사협회 신인학술상
2012. 11.
대한구강생물학회 청산학술상
1. Kim WJ, Kim BS, Kim HJ, Cho YD, Shin HL, Yoon HI, Lee YS, Baek JH, Woo KM, Ryoo HM.
Intratesticular Peptidyl Prolyl Isomerase 1 Protein Delivery Using Cationic Lipid-Coated Fibroin Nanoparticle Complexes Rescues Male Infertility in Mice. ACS Nano. 2020 Oct 27;14(10):13217- 13231. doi: 10.1021/acsnano.0c04936. Epub 2020 Oct 7. PMID:32969647.
2. Park D, Kim M, Choi JW, Baek JH, Lee SH, Baek K. Antimicrobial photodynamic therapy efficacy against specific pathogenic periodontitis bacterial species. Photodiagnosis Photodyn Ther. 2020 Jun;30:101688. doi: 10.1016/j.pdpdt.2020.101688. Epub 2020 Feb 19. PMID:32087294.
3. Suh J, Kim NK, Lee SH, Eom JH, Lee Y, Park JC, Woo KM, Baek JH, Kim JE, Ryoo HM, Lee SJ, Lee YS. GDF11 promotes osteogenesis as opposed to MSTN, and follistatin, a MSTN/GDF11 inhibitor, increases muscle mass but weakens bone. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4910-4920. doi: 10.1073/pnas.1916034117. Epub 2020 Feb 18. PMID:32071240.
4. Cho YD, Kim BS, Kim WJ, Kim HJ, Baek JH, Woo KM, Seol YJ, Ku Y, Ryoo HM. Histone acetylation together with DNA demethylation empowers higher plasticity in adipocytes to differentiate into osteoblasts. Gene. 2020 Apr 5;733:144274. doi: 10.1016/j.gene.2019.144274.
Epub 2019 Dec 3. PMID:31809844.
5. Park D, Gu H, Baek JH, Baek K. Undercarboxylated osteocalcin downregulates pancreatic lipase expression in an ATF4-dependent manner in pancreatic acinar cells. Bone. 2019 Oct;127:220-227.
doi: 10.1016/j.bone.2019.06.009. Epub 2019 Jun 16. PubMed PMID: 31216497.
6. Suh J, Eom JH, Kim NK, Woo KM, Baek JH, Ryoo HM, Lee SJ, Lee YS. Growth differentiation factor 11 locally controls anterior- posterior patterning of the axial skeleton. J Cell Physiol. 2019 Dec;234(12):23360-23368. doi:10.1002/jcp.28904. Epub 2019 Jun 10. PubMed PMID: 31183862;
PubMed Central PMCID: PMC6772169.
7: Qadir AS, Lee J, Lee YS, Woo KM, Ryoo HM, Baek JH. Distal-less homeobox 3, a negative regulator of myogenesis, is downregulated by microRNA-133. J Cell Biochem. 2019 Feb;120:2226-2235. doi:10.1002/jcb.27533. Epub 2018 Sep 11. PubMed PMID: 30277585.
8: Lee HL, Qadir AS, Park HJ, Chung E, Lee YS, Woo KM, Ryoo HM, Kim HJ, Baek JH.
cAMP/Protein Kinase A Signaling Inhibits Dlx5 Expression via Activation of CREB and Subsequent C/EBPβ Induction in 3T3- L1 Preadipocytes. Int J Mol Sci. 2018 Oct 14;19(10). pii: E3161. doi:
10.3390/ijms19103161. PubMed PMID: 30322210; PubMed Central PMCID: PMC6213991.
9: Islam R, Yoon H, Shin HR, Bae HS, Kim BS, Yoon WJ, Woo KM, Baek JH, Lee YS, Ryoo HM.
Peptidyl-prolyl cis-trans isomerase NIMA interacting 1 regulates skeletal muscle fusion through structural modification of Smad3 in the linker region. J Cell Physiol. 2018 Dec;233(12):9390-9403.
doi: 10.1002/jcp.26774. Epub 2018 Aug 21. PubMed PMID: 30132832; PubMed Central PMCID:
PMC6686165.
10: Shin HR, Bae HS, Kim BS, Yoon HI, Cho YD, Kim WJ, Choi KY, Lee YS, Woo KM, Baek JH, Ryoo HM. PIN1 is a new therapeutic target of craniosynostosis. Hum Mol Genet. 2018 Nov 15;27(22):3827-3839. doi: 10.1093/hmg/ddy252. PubMed PMID: 30007339; PubMed Central PMCID: PMC6216213.
11: Baek K, Park D, Hwang HR, Kim SG, Lee H, Baek JH. Blocking β₁/β₂-Adrenergic Signaling Reduces Dietary Fat Absorption by Suppressing Expression of Pancreatic Lipase in High Fat-Fed Mice. Int J Mol Sci. 2018 Mar 14;19(3). pii: E857. doi: 10.3390/ijms19030857. PubMed PMID:
29538343; PubMed Central PMCID: PMC5877718.
12: Baek K, Kang J, Lee J, Kim M, Baek JH. The Time Point-Specific Effect of Beta-Adrenergic Blockade in Attenuating High Fat Diet-Induced Obesity and Bone Loss. Calcif Tissue Int. 2018 Aug;103(2):217-226. doi: 10.1007/s00223-018-0407-3. Epub 2018 Feb 19. PubMed PMID:
29460182.
13: Rahman SU, Oh JH, Cho YD, Chung SH, Lee G, Baek JH, Ryoo HM, Woo KM. Fibrous Topography-Potentiated Canonical Wnt Signaling Directs the Odontoblastic Differentiation of Dental Pulp-Derived Stem Cells. ACS Appl Mater Interfaces. 2018 May 30;10(21):17526-17541. doi:
10.1021/acsami.7b19782. Epub 2018 May 18. PubMed PMID: 29741358.
14: Gu H, Song M, Boonanantanasarn K, Baek K, Woo KM, Ryoo HM, Baek JH. Conditions Inducing Excessive O-GlcNAcylation Inhibit BMP2-Induced Osteogenic Differentiation of C2C12 Cells. Int J Mol Sci. 2018 Jan 9;19(1). pii: E202. doi: 10.3390/ijms19010202. PubMed PMID: 29315243;
PubMed Central PMCID: PMC5796151.
15: Rahman SU, Park CH, Baek JH, Ryoo HM, Woo KM. Fibrin-Enhanced Canonical Wnt Signaling Directs Plasminogen Expression in Cementoblasts. Int J Mol Sci. 2017 Nov 9;18(11). pii: E2380.
doi: 10.3390/ijms18112380. PubMed PMID: 29120400; PubMed Central PMCID: PMC5713349.
16: Baek K, Park HJ, Baek JH, Kim HR. Isoproterenol Increases RANKL Expression in a ATF4/NFATc1- Dependent Manner in Mouse Osteoblastic Cells. Int J Mol Sci. 2017 Oct 20;18(10).
pii: E2204. doi: 10.3390/ijms18102204. PubMed PMID: 29053621; PubMed Central PMCID:
PMC5666884.
17: Zhang Q, Hwang JW, Oh JH, Park CH, Chung SH, Lee YS, Baek JH, Ryoo HM, Woo KM. Effects of the fibrous topography-mediated macrophage phenotype transition on the recruitment of mesenchymal stem cells: An in vivo study. Biomaterials. 2017 Dec;149:77-87. doi:
10.1016/j.biomaterials.2017.10.007. Epub 2017 Oct 4. PubMed PMID: 29017079.
18: Gu H, Boonanantanasarn K, Kang M, Kim I, Woo KM, Ryoo HM, Baek JH. Morinda citrifolia Leaf Extract Enhances Osteogenic Differentiation Through Activation of Wnt/β-Catenin Signaling. J Med Food. 2018 Jan;21(1):57-69. doi: 10.1089/jmf.2017.3933. Epub 2017 Oct 5. PubMed PMID:
28981378.
19: Islam R, Yoon H, Kim BS, Bae HS, Shin HR, Kim WJ, Yoon WJ, Lee YS, Woo KM, Baek JH, Ryoo HM. Blood- testis barrier integrity depends on Pin1 expression in Sertoli cells. Sci Rep. 2017 Aug 1;7(1):6977. doi: 10.1038/s41598-017-07229-1. PubMed PMID: 28765625; PubMed Central PMCID: PMC5539286.
20: Park CH, Oh JH, Jung HM, Choi Y, Rahman SU, Kim S, Kim TI, Shin HI, Lee YS, Yu FH, Baek JH, Ryoo HM, Woo KM. Effects of the incorporation of ε-aminocaproic acid/chitosan particles to fibrin on cementoblast differentiation and cementum regeneration. Acta Biomater. 2017 Oct 1;61:134-143. doi: 10.1016/j.actbio.2017.07.039. Epub 2017 Jul 29. PubMed PMID: 28764948.
21: Kim WJ, Kim BS, Cho YD, Yoon WJ, Baek JH, Woo KM, Ryoo HM. Efficiency data of intracellular recombinant protein delivery using cationic lipid coated silk fibroin particle. Data Brief. 2017 Jul 1;13:683-691. doi: 10.1016/j.dib.2017.06.041. eCollection 2017 Aug. PubMed PMID: 28725673;
PubMed Central PMCID: PMC5506864.
22: Park HJ, Baek K, Baek JH, Kim HR. TNFα Increases RANKL Expression via PGE₂- Induced Activation of NFATc1. Int J Mol Sci. 2017 Feb 24;18(3). pii: E495. doi: 10.3390/ijms18030495.
PubMed PMID: 28245593; PubMed Central PMCID: PMC5372511.
23: Zhang Q, Oh JH, Park CH, Baek JH, Ryoo HM, Woo KM. Effects of Dimethyloxalylglycine-Embedded Poly(ε-caprolactone) Fiber Meshes on Wound Healing in Diabetic Rats. ACS Appl Mater Interfaces. 2017 Mar 8;9(9):7950-7963. doi: 10.1021/acsami.6b15815. Epub 2017 Feb 27. PubMed PMID: 28211272.
24: Kim WJ, Kim BS, Cho YD, Yoon WJ, Baek JH, Woo KM, Ryoo HM. Fibroin particle-supported cationic lipid layers for highly efficient intracellular protein delivery. Biomaterials. 2017 Apr;122:154-162. doi: 10.1016/j.biomaterials.2017.01.019. Epub 2017 Jan 16. PubMed PMID: 28119155.
25: Bae HS, Yoon WJ, Cho YD, Islam R, Shin HR, Kim BS, Lim JM, Seo MS, Cho SA, Choi KY, Baek SH, Kim HG, Woo KM, Baek JH, Lee YS, Ryoo HM. An HDAC Inhibitor, Entinostat/MS-275, Partially Prevents Delayed Cranial Suture Closure in Heterozygous Runx2 Null Mice. J Bone Miner Res. 2017 May;32(5):951-961. doi: 10.1002/jbmr.3076. Epub 2017 Feb 28. PubMed PMID: 28052439.
26: Kim WJ, Islam R, Kim BS, Cho YD, Yoon WJ, Baek JH, Woo KM, Ryoo HM. Direct Delivery of Recombinant Pin1 Protein Rescued Osteoblast Differentiation of Pin1-Deficient Cells. J Cell Physiol. 2017 Oct;232(10):2798-2805. doi: 10.1002/jcp.25673. Epub 2017 May 5. PubMed PMID: 27800612.
27: Shin HR, Islam R, Yoon WJ, Lee T, Cho YD, Bae HS, Kim BS, Woo KM, Baek JH, Ryoo HM.
Pin1-mediated Modification Prolongs the Nuclear Retention of β-Catenin in Wnt3a-induced Osteoblast Differentiation. J Biol Chem. 2016 Mar 11;291(11):5555-65. doi:
10.1074/jbc.M115.698563. Epub 2016 Jan 6. PubMed PMID: 26740630; PubMed Central PMCID:
PMC4786698.
25: Bae HS, Yoon WJ, Cho YD, Islam R, Shin HR, Kim BS, Lim JM, Seo MS, Cho SA, Choi KY, Baek SH, Kim HG, Woo KM, Baek JH, Lee YS, Ryoo HM. An HDAC Inhibitor, Entinostat/MS-275, Partially Prevents Delayed Cranial Suture Closure in Heterozygous Runx2 Null Mice. J Bone Miner Res. 2017 May;32(5):951-961. doi: 10.1002/jbmr.3076. Epub 2017 Feb 28. PubMed PMID: 28052439.28: Cho YD, Bae HS, Lee DS, Yoon WJ, Woo KM, Baek JH, Lee G, Park JC, Ku Y, Ryoo HM.
Epigenetic Priming Confers Direct Cell Trans-Differentiation From Adipocyte to Osteoblast in a Transgene-Free State. J Cell Physiol. 2016 Jul;231(7):1484-94. doi: 10.1002/jcp.25183. Epub 2015 Dec 17. PubMed PMID: 26335354.
