Recent Publications

• Impact of denosumab therapy on periapical healing following root canal treatment: a 10-year retrospective case-control study 2026.09.12
  CONCLUSIONS: Within the limitations of this study, there was no statistically significant difference in the proportion of healed cases between patients receiving denosumab therapy and healthy controls. These findings suggest that non-surgical root canal treatment may remain a viable tooth-preserving treatment option for patients receiving denosumab therapy. Careful apical control and long-term follow-up may be […]
• Temporal astrocytic metabolic reprogramming gates pain chronification 2026.09.10
  Most experimental models of chronic pain emphasize the gradual emergence of sensory hypersensitivity, yet pain chronification can also be conceptualized as a metabolically regulated state transition. In this review, we synthesize evidence mainly from mouse and rat spinal cord and anterior cingulate cortex studies indicating that astrocytes temporally coordinate neuronal excitability, inflammatory signaling, and metabolic […]
• Intraoperative hypotensive burden with remimazolam versus propofol during ambulatory dental anesthesia in adults with intellectual disabilities: a retrospective within-subject study 2026.09.10
  CONCLUSION: In adults with intellectual disabilities undergoing ambulatory dental anesthesia, remimazolam-based maintenance was associated with less time below the prespecified relative MAP threshold than propofol-based maintenance. Because residual temporal and procedure-related confounding precludes causal inference, this finding should be considered hypothesis-generating.
• An Atlas of Specificity Protein 1 in Oral Cancer: Networks, Therapeutics, and Priorities: A Scoping Review and scRNA-seq Analysis 2026.09.10
  Oral squamous cell carcinoma (OSCC) remains the most common oral malignancy and has limited targeted therapeutic options. Specificity protein 1 (Sp1), a versatile zinc-finger transcription factor, has emerged as a pivotal regulator of cellular proliferation, apoptosis, epithelial-mesenchymal transition (EMT), and chemoresistance. However, OSCC-specific evidence has not been systematically integrated. This study synthesizes current evidence on […]
• Anomaly Localization and Classification of Jaw Cysts and Tumours Using Anatomy-Conditioned Diffusion on Panoramic Radiographs 2026.09.10
  CONCLUSIONS: DentalDiff+ combines normal-only diffusion-based anomaly localization with heat map-guided multi-class classification for jaw cysts and tumours on panoramic radiographs. By incorporating anatomy-conditioned denoising through ACN, the proposed method improved reconstruction fidelity and generated clinically meaningful anomaly cues while supporting lesion subtype classification. These findings suggest the potential of anatomy-conditioned diffusion for decision-support workflows,...
• Tooth Discoloration Potential of Coffee With Common Additives and the Effectiveness of Whitening Toothpastes in Stain Removal 2026.09.09
  CONCLUSION: Coffee additives affect the degree of tooth discoloration, with cream showing a protective effect. Both whitening toothpastes were effective, but the hydrogen peroxide formulation generally performed slightly better, potentially due to its deeper stain removal capability.
• Role-Differentiated AI Competencies and Curriculum Implications for Health Professions Education: Qualitative Study 2026.09.08
  CONCLUSIONS: This study identifies role-differentiated AI competencies and proposes a corresponding curriculum scaffold for healthcare education. As a preliminary, hypothesis-generating starting point requiring multistakeholder validation, the proposed framework can help prepare the future healthcare workforce to utilize AI responsibly and to govern and lead the next generation of digital health innovation.
• BMP9-loaded collagen scaffold promotes periodontal regeneration via microenvironmental modulation of PDLSCs and macrophages 2026.09.08
  Periodontal tissue regeneration requires coordinated cellular responses among multiple cell types, supporting matrix components, and signaling proteins, including bone morphogenetic proteins (BMPs). Despite extensive studies on BMP2, the regenerative role of BMP9 and its interplay with BMP2 in shaping bone and cementum repair remain poorly understood. Notably, BMP9 was independent of the antagonist Noggin, and […]
• Pyruvylation expands the redox repertoire of lysine acylation 2026.09.07
  Song et al. establish lysine pyruvylation (Kpy) as an acylation response to glycolytic flux and pyruvate availability, detect pyruvyl-CoA, implicate histone acetyltransferase 1 and p300 as writers and sirtuin 3 as an eraser, and link promoter-associated histone Kpy to transcriptional regulation, defining a distinct C3 acylation alongside lactylation at the redox-coupled pyruvate-lactate node.
• A narrative review of artificial intelligence in dental imaging: from dataset design to clinical translation 2026.09.07
  CONCLUSIONS: AI has demonstrated considerable potential for automated classification, detection, segmentation, and decision support in dental imaging. However, challenges including dataset heterogeneity, annotation inconsistency, domain shift, information leakage, interpretability, and regulatory requirements continue to limit clinical adoption. Emerging approaches such as multimodal learning and foundation models may improve generalizability and clinical applicability.
• Multimodal Large Language Models for Dental Chart Image Interpretation: Cross-Sectional Benchmarking Study With Students and Clinicians 2026.09.04
  CONCLUSIONS: Statistically nonsignificant differences were observed between GPT-5 Thinking and dental students for most question-type contrasts, with Student 2 differing only on absent-information items. Compared with first-year residents, GPT-5 Thinking remained lower on several Type A-C contrasts, particularly interpretive Type C and one tooth- or procedure-specific Type B comparison; Type D contrasts require cautious interpretation […]
• Special AT-rich sequence binding protein 2 (SATB2), β-catenin, and CD10 immunohistochemistry provides insights into the histopathologic features and cellular differentiation of adenomatoid odontogenic tumor 2026.09.03
  CONCLUSION: SATB2, β-catenin, and CD10 immunohistochemistry provides novel insights into the histopathologic patterns, cellular differentiation, and tumor development of AOT and may aid in its diagnosis.
• From milling to printing: evaluating the applicability of zirconia in restorative dentistry 2026.09.03
  CONCLUSION: 3D-printed zirconia showed flexural strength comparable to milled zirconia and demonstrated favorable adaptation in selected regions, although optical properties were lower.
• Prosthodontics should be art founded on science, not merely art and science 2026.09.03
  No abstract
• Peritumoral bone changes in mandibular gingival squamous cell carcinoma: A prospective radiologic-histopathologic correlation study 2026.09.03
  CONCLUSION: Most peritumoral bone changes observed on CT and MRI in mandibular gingival SCC were found to be reactive rather than truly invasive on histopathologic evaluation. Differentiating these changes has prognostic value and helps identify patients with poorer survival.
• Changes in oral health-related quality of life and self-esteem after fixed orthodontic treatment 2026.09.02
  CONCLUSIONS: After orthodontic treatment, OHRQoL improved in both sexes and SE improved in female patients, although the clinical significance of these changes was uncertain. In the extraction group, OHRQoL and SE were initially lower than those in the non-extraction group but showed no significant intergroup differences after treatment.
• Host nucleolin-targeting unique peptide drugs as potent broad-spectrum anti-influenza therapies 2026.09.02
  The persistent threat of influenza pandemics and seasonal outbreaks, coupled with rising resistance to existing antiviral drugs targeting influenza viruses, necessitates the development of new therapeutics. This study investigated the antiviral potential of cell-penetrating peptide-conjugated host nucleolin (NCL)-binding peptide drugs, AGM-380d (dimeric) and AGM-380t (tetrameric), as innovative, broad-spectrum host-directed anti-influenza therapies. Infection with both influenza […]
• Association between periodontal disease severity and the risk of medication-related osteonecrosis of the jaw: a systematic review and meta-analysis by the Korean Academy of Periodontology 2026.09.02
  CONCLUSIONS: Current evidence supports an association between PD and increased MRONJ risk in patients receiving antiresorptive or antiangiogenic therapy. Although the subgroup findings suggest that more advanced periodontal breakdown may be associated with greater risk, this severity-based pattern should be interpreted cautiously and confirmed in future studies with larger sample sizes and standardized diagnostic criteria.
• Analgesic mechanism of Panaphix in spinal nerve-ligated rats: involvement of microglial inflammatory cytokines 2026.09.02
  CONCLUSIONS: PAX-1 demonstrated potent anti-allodynic and anti-inflammatory effects in an SNL-induced neuropathic pain model. These findings indicate that PAX-1 may exert analgesic effects primarily through modulation of IL-1β-mediated microglial activation, suggesting its therapeutic potential for neuropathic pain management.
• Clinical pathways in occlusal dysesthesia: A scoping review of recognition failure, repeated dental intervention, and iatrogenic risk 2026.09.01
  CONCLUSIONS: Results are consistent with a proposed escalation pathway but establish neither frequency nor causality. After structural assessment, early recognition, avoiding irreversible occlusal treatment, and coordinated biopsychosocial care may reduce iatrogenic burden.