Recent Publications

• CASKIN2 mediates PTPσ-orchestrated transsynaptic mechanisms at excitatory synapses 2025.11.12
  Presynaptic active zones (AZs) perform essential functions in orchestrating speedy and accurate neurotransmission. Despite extensive studies on their molecular constituents, it remains unclear how transsynaptic signals are organized at AZs. The two members of the CASKIN family of multidomain scaffold proteins, CASKIN1 and CASKIN2, bind to several AZ proteins and LAR receptor protein tyrosine phosphatases […]
• A novel cross-attentive network for classifying cervical metastatic lymph nodes on B- and D-mode ultrasound images in oral squamous cell carcinoma 2025.11.09
  CONCLUSION: LNM-Net demonstrates strong potential as a clinical decision-support tool for preoperative lymph node metastasis assessment in oral squamous cell carcinoma. Despite current limitations such as dataset size and cross-institutional variability, the model offers a promising supplementary aid, particularly in settings with limited radiological expertise.
• Concomitant Headache and Its Association With Worse Psychological and Clinical Status in Temporomandibular Disorders 2025.11.08
  CONCLUSIONS: TMD patients when reporting concomitant headache showed higher pain levels, widespread pain, and higher levels of psychological distress. The results indicate the need to appropriately address the issue of headache in TMD patients with an emphasis on psychological issues to improve overall prognosis.
• Factors affecting the fit of metal‑based restorations fabricated by selective laser melting: A systematic review 2025.11.08
  CONCLUSIONS: Within the limitations of current evidence, clinically acceptable fit was associated with cobalt chromium alloys printed at 0 or 30 degrees with a 25- to 50-µm layer thickness and optimized laser parameters. In contrast, a 90-degree printing orientation often resulted in marginal gaps exceeding acceptable thresholds.
• Research Trends in Medical and Dental Education (2015-2024) Based on Author Keywords: Commonalities, Differences, and Opportunities for Collaboration 2025.11.07
  CONCLUSION: This study identifies both foundational commonalities and discipline-specific innovations in medical and dental education research over the past decade. These findings suggest that shared interests and distinctive priorities can lead to meaningful opportunities for collaborative educational development and joint research efforts across health professions education.
• TUSC3 regulates ERMA-mediated Mg²⁺ uptake for synaptic function and neurodevelopment 2025.11.07
  Intellectual disability (ID) is characterized by deficits in cognition and adaptive behavior, with few treatment options. Tumor Suppressor Candidate 3 (TUSC3) has been genetically linked to autosomal recessive ID, but its molecular mechanism and therapeutic potential remain unclear. Here we show that TUSC3 is essential for endoplasmic reticulum (ER) Mg²⁺ homeostasis and neuronal function. Using […]
• Glioblastoma Immunotherapy Adjuvants for Glial Cell Polarization Regulation 2025.11.04
  Glioblastoma (GBM) remains fatal despite maximal surgical resection, temozolomide chemotherapy, and radiotherapy. Within the GBM microenvironment, tumor-educated microglia and astrocytes adopt immunoregulatory-like STAT3-high and ARG1/TGF-β-high phenotypes, respectively, which shield GBM cells from adaptive immune attack. In this review, we examine emerging adjuvant strategies designed to molecularly reprogram glial cells toward pro-inflammatory C3-high and IFN/NF-κB-high states, […]
• AXIN2 variants, tooth agenesis, and cancer risk: a systematic review 2025.11.04
  CONCLUSIONS: Tooth agenesis, especially in individuals with AXIN2 variants affecting the SMAD3 domain, may serve as a clinical marker for identifying individuals at increased cancer risk. Recognizing congenital missing teeth in patients with AXIN2 mutations can aid in early cancer screening, improving early detection and outcomes through timely interventions and surveillance.
• Comparing impression techniques in the prosthodontic treatment for edentulous patients: a 3D finite element analysis 2025.11.03
  CONCLUSION: Selective pressure trays modified tissue loading locally at the relief site; however, these did not seem to provide a substantial biomechanical advantage, particularly on bone. Their clinical relevance remains limited and needs further supporting evidence.
• Osseointegration properties of niobia-modified yttria-stabilized zirconia implant surface: an <em>in vivo</em> study 2025.11.03
  CONCLUSION: Sandblasted (Y,Nb)-TZP implants indicated superior osseointegration in comparison to SLA titanium and smooth-surface 3D-printed 3Y-TZP implants. The enhanced osseointegration observed in this study supports the clinical potential of (Y,Nb)-TZP as a next-generation zirconia implant material.
• Comparisons of optical characteristics between 3D printed dental resins and resin composites 2025.11.03
  PURPOSE: To compare the optical characteristics of 3D-printed resins and conventional resin composites, focusing on color differences, whiteness index, and translucency under varying specimen thicknesses and polishing conditions.
• Celebrating a new chapter in international collaboration 2025.11.03
  No abstract
• Association between oral health and physical frailty in community-dwelling older adults: A systematic review and meta-analysis 2025.11.01
  CONCLUSIONS: This systematic review demonstrated that poor oral health and impaired oral function were significantly associated with physical frailty among older adults. These findings strongly support incorporating oral health screenings into routine geriatric assessments to identify older adults at risk of physical frailty and to inform targeted preventive strategies.
• HDAC inhibitors restore osteoimmune balance and bone regeneration via selective MAPK modulation in inflammatory bone disease 2025.11.01
  CONCLUSIONS: TSA, PXD, and MGCD function as dual-action therapeutics by regulating macrophage polarization and enhancing osteogenesis, thereby establishing a pro-regenerative microenvironment and reversing inflammatory bone loss. These findings provide mechanistic insight into the epigenetic control of immune-bone crosstalk and support a drug-repurposing strategy that utilizes clinically available HDAC inhibitors to accelerate the development of osteoimmunomodulatory […]
• Mannose phosphotransferase system subunit IID of Streptococcus mutans elicits maturation and activation of dendritic cells 2025.10.30
  Streptococcus mutans is a Gram-positive pathogen that causes dental caries and subsequent pulpal infection leading to pulpitis. Although dendritic cells (DCs) are known to be involved in disease progression and immune responses during S. mutans infection, little is known about the component of S. mutans responsible for the DC responses. Although the mannose phosphotransferase system […]
• Risk factors and treatment outcomes in osteoradionecrosis in head and neck cancer patients: a retrospective analysis 2025.10.29
  CONCLUSION: This study underscores the prognostic relevance of treatment modality in ORNJ management. Partial mandibulectomy appears to confer more favorable outcomes in advanced-stage ORNJ, although its invasive nature necessitates individualized treatment planning. Future prospective studies incorporating dosimetric parameters and long-term follow-up are warranted to establish evidence-based guidelines for ORNJ treatment.
• Digital impression accuracy for bone-level and tissue-level implants using scan bodies of different heights 2025.10.28
  Intraoral scanning has gained acceptance for its accuracy comparable to conventional implant impressions. This study compared digital impression accuracy based on implant placement level and scan body height. Two mandibular partial edentulous models missing the left second premolar and first molar, were used: one with a tissue level implant and the other with a bone […]
• PRDX5 Regulates Mitochondrial Function and Nuclear Spreading in Myogenesis and Acts With PRDX3 to Delay Muscle Aging 2025.10.28
  CONCLUSIONS: Our findings reveal a previously unidentified role of PRDX5 in coordinating mitochondrial function and nuclear positioning during myogenesis and muscle regeneration. The combined deficiency of PRDX3 and PRDX5 accelerates muscle aging by exacerbating oxidative stress and mitochondrial dysfunction, suggesting that enhancing their activity may be a promising therapeutic strategy to prevent sarcopenia and age-related […]
• Effects of delayed post-polymerization on physical, chemical, and biological properties of a 3D printing interim resin 2025.10.28
  OBJECTIVES: This study evaluated the effects of delayed post-polymerization on color, degree of conversion (DC), flexural strength (FS), and cellular response of a 3D-printed dental interim resin.
• Serdemetan promotes bone regeneration via coordinated regulation of osteoblast and osteoclast activity 2025.10.25
  Although murine double minute 2 (MDM2) inhibitors are known for their anti-cancer effects via p53 activation, their potential role in bone regeneration remains largely unexplored. In this study, we systematically screened 22 MDM2 inhibitors and identified serdemetan as the best candidate according to its dual functionalities of promoting osteogenesis and inhibiting osteoclastogenesis. Therefore, we adopted […]