Recent Publications

• Cereblon-related mild intellectual disability disrupts response inhibition and uniformity of group-individual strategies 2026.07.28
  Temporal processing, including duration discrimination, is essential for survival and communication across species. Intellectual disability (ID), which can arise from diverse causes, including mutation in Cereblon (CRBN) gene, impairs duration discrimination. CRBN-related ID is associated with abnormal cognitive behaviors and may disrupt both perceptual and behavioral processes involved in duration discrimination. However, cross-species behavioral strategies, […]
• Antipsychotics-Induced Hyposalivation Mediated by Impaired Salivary Ca²⁺ Signaling 2026.07.27
  CONCLUSIONS: Our findings indicate that antipsychotic-induced hyposalivation can be driven by the direct peripheral inhibition of muscarinic receptors within the salivary glands, rather than through dopaminergic or serotonergic antagonism, and support the mechanism-based preventive protocols for patients on long-term antipsychotic therapy.
• Viscosity of Carboxymethylcellulose, Hydroxyethylcellulose and Polyethylene Glycol and Their Effect on Salivary Enzymes 2026.07.27
  CONCLUSIONS: CMC, HEC and PEG differentially affected antimicrobial enzymatic activities, with the direction and magnitude of effects dependent on polymer type, MW, concentration and enzyme source.
• Severity-Graded MRI-Detected TMJ Effusion Is Associated With Pain and Dysfunction in Temporomandibular Disorder Patients 2026.07.25
  CONCLUSIONS: Severity-graded MRI-detected TMJ effusion is associated with greater pain intensity and dysfunction in patients with TMJ arthralgia, supporting its interpretation as a clinically meaningful imaging marker rather than an incidental radiologic finding.
• Integrative Multi-omics and Single-Cell Profiling Identify Cell-Type-Resolved Inflammatory Drivers in Symptomatic Irreversible Pulpitis 2026.07.22
  CONCLUSIONS: These findings provide a cell-type-resolved view of pulpitis-associated inflammatory drivers. may provide candidate molecular readouts for future studies of pulpitis-associated inflammatory activity.
• How Much Inter-Arch Discrepancy Occurs During Orthognathic Surgery? 2026.07.21
  CONCLUSIONS AND RELEVANCE: Interarch discrepancy showed a statistically significant inferior displacement across regions, although its overall magnitude was modest.
• Automated forensic human identification on dental panoramic radiographs using transformer-based detection with supervised metric learning 2026.07.21
  CONCLUSIONS: The proposed detection-based metric learning framework provides a practical pre-screening tool that compresses exhaustive AM-PM database comparisons into a ranked shortlist of candidates for forensic expert verification. The system is intended to operate upstream of expert verification rather than to replace in disaster victim identification and missing person investigations.
• Biomimetic, self-healing occlusive hydrogel membranes for effective guided bone regeneration 2026.07.18
  CONCLUSION: HAPPHy hydrogels showed favorable physicochemical, mechanical, and biological performance and may represent potential candidates for further investigation as an occlusive membrane for guided bone regeneration.
• Aquaporin-5-specific heavy chain VDJ knock-in (A5H) mice reveal molecular mimicry-driven initiation and diversification of autoreactive B-cell responses 2026.07.17
  Molecular mimicry, where microbial antigens resemble self-antigens, is implicated in triggering autoimmune responses, yet the early B-cell events leading to autoantibody production remain unclear. Here, we generated A5H mice, a knock-in model in which a heavy chain binding to the aquaporin-5 (AQP5) "E" epitope (AQP5E) preferentially generates B cells recognizing a microbial mimic peptide (PmE-L). […]
• Effects of adhesive application timing on the push-out bond strength of four calcium silicate-based cements: a comparative study in vitro 2026.07.15
  CONCLUSIONS: Within the limitations of this experimental design, adhesive application 1 h after placing premixed CSBC adversely affected the 7-day POBS of EC. The POBS was higher for TheraCal PT than premixed-type CSBCs when evaluated using Prime & Bond Universal in self-etch mode after storage for 7 days.
• Automated Adaptive Approach for Specular Highlight Removal in Digital Dentistry: A Proof-of-Concept Study for Preserving Tooth Surface Texture 2026.07.15
  Background/Objectives: Digital intraoral photography is widely used for clinical documentation, longitudinal monitoring, and AI-assisted dental image analysis. However, specular highlights caused by saliva and intense illumination can obscure tooth texture and compromise image fidelity. This study aimed to develop an automated method for removing specular highlights from intraoral images while preserving tooth surface texture. Methods: […]
• Tailored Ion Release of Polycaprolactone and Calcium Silicate Composite Fibers Attenuates Neutrophil Extracellular Trap Formation for Dentin-Pulp Complex Regeneration 2026.07.15
  While calcium silicate (CS) remains a gold standard material for vital pulp therapy, its clinical efficacy is frequently compromised by an abrupt ion release during the initial setting phase that induces extreme alkalinity and acute cytotoxicity. We engineered electrospun poly-ε-caprolactone (PCL)/CS composite fibers to reconfigure CS hydration kinetics, achieving sustained and controlled ion release. In […]
• Explainable AI Consensus for Grading Human Blastocysts and Blastoids 2026.07.15
  ABSTRACT: The morphological evaluation of human blastocysts is a critical yet subjective step in clinical assisted reproductive technology, often limited by inter-observer variability. To establish a standardized and objective grading system for both clinical blastocysts and stem cell-derived blastoids, we developed an explainable artificial intelligence-driven multi-model consensus framework. Our methodology utilized a large-scale dataset of […]
• Bio-inspired polyphenol-polyelectrolyte WRAP system for geometrically controlled AAV delivery in diverse anatomical sites 2026.07.13
  Systemic delivery of therapeutics frequently requires elevated dosing to achieve effective local concentrations, often resulting in unintended toxicity and insufficient drug levels at the target site. To address this inherent limitation, localized drug and gene delivery strategies have been developed to deposit therapeutic payloads directly within diseased microenvironments. Herein, we report the development of a […]
• Chitosan coating effects on biological response to niobia-modified yttria-stabilized zirconia 2026.07.10
  CONCLUSION: Although Ch promoted osteogenic activity in vitro, these effects did not translate in vivo, and the coating failed to enhance osseointegration on Y,Nb-TZP implants. This gap underscores the complexity of host responses and the need to refine Ch properties for further evaluation under clinically relevant conditions.
• Prosthodontic treatment must remain grounded in science 2026.07.10
  No abstract
• Psychometric evaluation of the Korean version of the Child Oral Health Impact Profile administered online among schoolchildren: a cross-sectional study 2026.07.10
  CONCLUSION: The Korean COHIP-34, administered online, showed acceptable psychometric properties, suggesting that it may be a practical tool for assessing OHRQoL in large-scale epidemiological studies and school-based oral health programs.
• Transgender Identity Dimensions and Unmet Dental Care Needs Among Korean Transgender Adults 2026.07.10
  CONCLUSIONS: Passing emerged as the most robust psychosocial predictor of unmet dental care among Korean transgender adults, with Pride and Shame exhibiting classical suppression in joint models. Gender-affirming hormone therapy was a strong enabling factor. These findings suggest that trans-affirming dental care should address interpersonal competency and anticipated identity exposure barriers, tailored by transition stage […]
• Lymph node-targeted mRNA delivery of fine-tuned peptide-nanocomplexes for SARS-CoV-2 Vaccination 2026.07.09
  Messenger RNA (mRNA) vaccines require efficient delivery systems to reach antigen-presenting cells (APCs). Lipid nanoparticles (LNPs) are a standard delivery carrier. However, LNPs often accumulate in the liver and exhibit transient protein expression. These limitations can restrict their safety and immunogenic potential. Here, we developed a modular, peptide-based nanocomplex to overcome the current limitations. The […]
• Mechanisms Underlying Burning Mouth Syndrome and Occlusal Dysesthesia: Shared and Distinct Pathways of Oral Sensory Dysregulation 2026.07.06
  CONCLUSION: BMS and OD may represent distinct but partially overlapping phenotypes within a broader framework of oral sensory dysregulation. Recognition of shared and divergent mechanisms may improve differential diagnosis, support mechanism-informed pharmacological management, and guide future hypothesis-driven research in oral medicine.