Recent Publications

• Cholesterol Sulfate as a Negative Regulator of Cellular Cholesterol Homeostasis 2025.03.15
  Cholesterol sulfate (CS), one of the most abundant cholesterol derivatives, recently emerged as a key regulatory molecule in several physiological processes. Here, we demonstrate multiple mechanisms by which CS reduces intracellular cholesterol levels. CS promotes the proteasomal degradation of HMG-CoA reductase (HMGCR) by enhancing INSIG-mediated ubiquitination, thereby inhibiting cholesterol synthesis. In addition, CS blocks low-density […]
• Advanced 3D biomimetic scaffolds with bioactive glass and bone-conditioned medium for enhanced osteogenesis 2025.03.13
  The study focuses on developing and evaluating 3D biomimetic fibrous scaffolds to enhance osteoblast differentiation and bone tissue regeneration. Utilizing a synergistic approach, biological and chemical factors were compartmentalized within the fibrous scaffolds through co-axial electrospinning. Bioactive glass (BG) was used for osteo-conductivity, and Bone-Conditioned Medium (BCM) for osteoinduction. The BCM, derived from ovine bone […]
• Microbiota associated with caries and apical periodontitis: A next-generation sequencing study 2025.03.12
  CONCLUSION: Bacterial community structure differed significantly between biofilm and root canal samples, but showed no significant differences among biofilm samples based on dental caries status. However, some taxa were shared among caries-affected lesions, including dentine and root canals. H. multisaccharivorax, O. uli, L. gasseri, Selenomonadaceae species and S. inopinata exhibited higher abundance in caries-affected dentine […]
• Deciphering a crosstalk between biological cues and multifunctional nanocarriers in lung cancer therapy 2025.03.10
  In recent years, the utilization of nanocarriers has significantly broadened across a diverse spectrum of biomedical applications. However, the clinical translation of these tiny carriers is limited and encounters hurdles, particularly in the intricate landscape of the tumor microenvironment. Lung cancer poses unique hurdles for nanocarrier design. Multiple physiological barriers hinder the efficient drug delivery […]
• Advancing the Korean Academy of Periodontology through member participation 2025.03.06
  No abstract
• Polynucleotide with cross-linked hyaluronic acid reduces inflammation and increases collagen synthesis 2025.03.06
  CONCLUSIONS: Within the limitations of this study, we concluded that PN/HA improves gingival tissue healing by promoting cell proliferation and migration, facilitating rapid collagen deposition, and exerting anti-inflammatory effects.
• Standard operating procedures for quality control of oral biospecimens at the Korea Oral Biobank Network 2025.03.06
  CONCLUSIONS: To ensure a stable supply of high-quality biospecimens for researchers, regular QC checks should be carried out according to the SOP following the specifications of the Korea Biobank Network under the Korea Disease Control and Prevention Agency.
• <em>In vitro</em> evaluation of prosthesis-level implant stability using 'BracketPeg' 2025.03.06
  CONCLUSIONS: BracketPeg provides reliable and consistent implant stability measurements at the prosthesis level compared to other devices, making it a practical and feasible tool for the clinical evaluation of implants.
• Bone regeneration and biosorption patterns of different bone substitutes: an <em>in vivo</em> study in rabbit skulls 2025.03.06
  CONCLUSIONS: All types of bone substitutes demonstrated similar patterns of bone regeneration at both 6 and 12 weeks of observation. However, cancellous DPBM exhibited a higher rate of bioabsorption compared to other bone substitutes, suggesting that it may have different indications or applications in guided bone regeneration protocols.
• The Burden of Care for Cervical Necrotizing Fasciitis in a Resource-constrained Setting 2025.03.03
  Necrotizing fasciitis (NF) is a soft tissue infection that is primarily characterized by fast spread along the fascial planes and adjacent cutaneous tissues. Cervico-facial necrotizing fasciitis (CNF) usually presents with severe intense pain with a polymicrobial odontogenic source. Early diagnosis with aggressive management, usually involving appropriate antibiotic selection, surgical debridement, and wound care, is key […]
• Bone mineral density and anatomic limitations of miniscrew placement at buccal interradicular sites: A quantitative computed tomography study 2025.03.03
  CONCLUSIONS: Regarding BMD, all interradicular sites from the canines to the second molars may be adequate candidates for miniscrew placement, regardless of growth state and sex. Anatomic limitations should be carefully considered when placing miniscrews, specifically between the maxillary molars.
• Unraveling the dynamics of osteoblast differentiation in MC3T3-E1 cells: Transcriptomic insights into matrix mineralization and cell proliferation 2025.03.03
  Unraveling the intricacies of osteoblast differentiation is crucial for advancing our comprehension of bone biology. This study investigated the complicated molecular events orchestrating osteoblast differentiation in MC3T3-E1 cells, a well-established in vitro culture model. Employing longitudinal RNA-sequencing analysis, we explored transcriptomic changes at the pivotal time points of 0, 1, 4, 7, 10, 14, and […]
• Intraosseous xanthoma simultaneously treated with mandibular prognathism using sagittal split ramus osteotomy in the mandible: a case report and literature review 2025.02.28
  Xanthomas are benign lesions characterized by the aggregation of lipid-laden histiocytes and foamy cells within tissues. Intraosseous xanthomas (IOXs), especially those in the jaw bone, are rare, with only around 50 cases documented. This case report describes an IOX located at an osteotomy site in the mandible during sagittal split ramus osteotomy (SSRO). Preoperative radiographs […]
• Factors influencing proximal contact loss between fixed implant prostheses and adjacent natural teeth: a retrospective study 2025.02.28
  CONCLUSION: The occurrence of PCL between implant prostheses and adjacent teeth is influenced by the pre-existing interproximal gap between consecutive natural teeth adjacent to the implant. This factor should be carefully monitored.
• Prognostic factors influencing implant survival and marginal bone loss in patients with osteoporosis or osteopenia medication 2025.02.28
  CONCLUSION: The implant survival rate in patients undergoing medical treatment for osteoporosis or osteopenia was comparable to the general implant survival rate. MBL before prosthetic treatment was associated with type of anti-osteoporotic medication, whereas MBL after prosthetic treatment was correlated with drug administration route. Further studies with larger sample sizes are required.
• Prenatal Dental Visits, Perceived Benefits of Oral Health, and Preterm Birth Outcome, 2009-2021 2025.02.27
  CONCLUSION: This study revealed an inverse relationship between dental cleaning visits during pregnancy and preterm birth outcomes, notably among women who recognized the benefits of oral health and among non-Hispanic White women. The results emphasize the significance of dental visits and the perception of oral health benefits during pregnancy.
• Antibodies with specificity to glycan motifs that decorate OMV cargo proteins 2025.02.26
  Porphyromonas gingivalis is a major etiological agent of periodontal disease, and infections with this bacterium are associated with systemic pathologies, including atherosclerosis, rheumatoid arthritis, and Alzheimer's disease. P. gingivalis has a variety of immune evasion mechanisms and exhibits highly variable cell surface characteristics that are strain dependent, complicating the development of effective vaccines and therapeutics. […]
• Impact of demineralization, brushing, and remineralization sequences on dentin mineral retention and surface properties 2025.02.26
  This study investigates the effects of different treatment sequences involving demineralization, brushing, and remineralization on the calcium and phosphorus (Ca/P) content, surface roughness, and microhardness of dentin specimens. Bovine dentin samples were subjected to the following five treatment conditions: control, demineralization, demineralization followed by remineralization, demineralization followed by brushing then remineralization, and demineralization followed by […]
• Comparative analysis of acute and chronic painful temporomandibular disorders: Insights into pain, behavioral, and psychosocial features 2025.02.25
  CONCLUSION: Chronic pain was more prevalent in PT patients and associated with greater severity in pain, behavioral, and psychosocial variables. Pain intensity and oral behaviors were linked to an increased likelihood of chronic pain.
• Trueness of Customized Abutment Data Superimposition on Incompletely Scanned Impression: An In Vitro Study 2025.02.22
  CONCLUSIONS: Superimposing abutment library data improve the trueness of intraoral scans, even when areas along margins and proximal surfaces are incomplete.