Recent Publications

• Altered trafficking of Kv1-Kvβ2 leads to neuronal hyperexcitability and memory deficits in amyloid-β pathology 2026.03.11
  No abstract
• Real-Time Assessment of Dentinal Fluid Flow Reduction by Desensitising Agents Using Subnanolitre Flow Measuring System 2026.03.11
  CONCLUSION: Desensitising toothpastes reduced dentinal permeability to levels comparable to a sodium fluoride varnish. Real-time fluid flow measurement using NFMD enabled functional validation of dentinal tubule occlusion beyond surface morphology.
• Bone Morphogenetic Protein (BMP) 9 Outperforms BMP2 in Osteogenesis and Osseointegration: In Vitro and In Vivo 2026.03.10
  CONCLUSIONS: BMP9 showed stronger osteoinductive potential than BMP2, resulting in improved bone regeneration and osseointegration. These findings suggest that BMP9 is a promising growth factor for improving dental implant outcomes.
• Dental Implants in Adults With Intellectual Disabilities: A Multicenter Retrospective Study. Part 1: Implant Outcomes 2026.03.07
  CONCLUSIONS: Dental implant therapy represents a viable long-term treatment option for adults with non-syndromic ID. Despite the clinical challenges of this population, high survival and success rates can be achieved, particularly when appropriate implant selection, prosthetic retention systems, and behavioural management techniques are implemented.
• Clinical outcomes and mechanical evaluation of patient-specific mandibular reconstruction following tumor resection: a retrospective study with finite element analysis 2026.03.07
  No abstract
• Letter from the New Editor-in-Chief 2026.03.05
  No abstract
• A Microfluidic Cell Culture Platform for Modeling Aligned Peripheral Nerve Bundle, Connection, and Myelination 2026.03.04
  The development of microfluidic platforms has advanced peripheral nervous system research; however, traditional polydimethylsiloxane (PDMS)-based systems lack scalability and physiological relevance. To overcome these limitations, we introduce a 3D-printed organ-on-a-chip that enables precise sensory neurite alignment and myelination studies in a standardized 384-well format. Our platform integrates open and closed microfluidic principles to ensure stable […]
• Prediction and risk factor analysis of dental implant failure using Cox regression and machine learning 2026.02.28
  CONCLUSIONS: RSF showed good, but not superior, predictive accuracy compared with the best-performing Cox model. The choice of analytical method for implant survival studies should consider model complexity in relation to the dataset's sample size and event rate.
• Peri-implantitis as a potential risk factor for peri-implant oral malignancy 2026.02.27
  Peri-implant oral malignancy (PIOM) refers to malignant tumors arising around dental implants and is an increasingly reported complication of implant therapy. PIOM may follow distinct pathophysiological mechanisms, including chronic peri-implant inflammation and implant-related factors that contribute to carcinogenesis. This current review aims to explore the potential role of peri-implantitis (PI) as a risk factor for […]
• Three-dimensional evaluation of soft tissue contour changes after premolar extraction with and without alveolar ridge preservation: A prospective observational study 2026.02.27
  CONCLUSIONS: Intraoral scanning combined with digital superimposition proved effective for evaluating soft tissue changes after extraction. While ARP remains a valuable approach for alveolar bone preservation, its additional impact on soft tissue contour was limited in sites with favorable baseline conditions.
• Structure-Property-Function Evaluation of a β-Type Ti-Nb-Zr Alloy for Dental Implant Applications with Short-Term Clinical Validation 2026.02.26
  Titanium-based alloys are widely used in dental implantology; however, the mechanical limitations of commercially pure titanium (cpTi) and unresolved concerns regarding stress shielding remain. This study evaluated the structure-property-function relationship of a novel β-type titanium-niobium-zirconium (Ti-Nb-Zr; TNZ) alloy for dental implant applications. Laboratory testing assessed the elemental composition, tensile properties, and fatigue resistance of the […]
• Dimensional accuracy and internal fit of anterior 3-unit fixed dental prostheses fabricated by additive and subtractive manufacturing using polymer-based and ceramic restorative materials 2026.02.22
  CONCLUSIONS: AM-UA exhibited significantly higher dimensional accuracy at the internal and marginal regions of the anterior 3-unit FDPs compared with SM-GP. Although SM-HP showed the best internal fit and AM-UA exhibited the poorest, the internal fit of all tested FDPs was close to or below clinically acceptable thresholds.
• Integrating Oral Health into Primary Health Care for Refugees: A Content Analysis of Health Strategies of International Refugee Health Organizations 2026.02.20
  No abstract
• Supportive Periodontal Therapy Improves Implant Survival in Patients With a History of Periodontitis: A Retrospective Multicenter Cohort Study of 3555 Implants 2026.02.15
  CONCLUSION: Bone-level internal connection SA implants demonstrated favorable long-term survival. However, periodontitis-related tooth loss, GBR, and SPT compliance significantly affected implant longevity, emphasizing individualized risk assessment and continuous maintenance care. The absence of longitudinal radiographic bone-level data limits further evaluation of peri-implant bone stability.
• Xerostomia in Patients With and Without Concomitant Oral Burning Pain And/Or Dysesthesia 2026.02.14
  CONCLUSION: The severity of xerostomia in patients with xerostomia alone is closely linked to salivary gland function, whereas in patients with xerostomia and concomitant oral burning pain and/or dysesthesia, it is more strongly influenced by the severity of these symptoms and psychological distress.
• Acquisition of amantadine resistance via M gene reassortment in canine H3N2 influenza virus and elucidation of the resistance mechanism 2026.02.14
  A novel variant of the canine influenza virus H3N2 (cH3N2), designated as the M variant, was identified as containing a matrix (M) gene segment derived from the 2009 pandemic H1N1 virus (pdmH1N1), raising concerns regarding potential changes in antiviral drug sensitivity. In vitro and in vivo antiviral susceptibility assays demonstrated that while the parental cH3N2 […]
• Bone regenerative capacity of the newly synthesized material QG3030: an <em>in vitro</em> and <em>in vivo</em> study 2026.02.10
  CONCLUSIONS: Combining QG3030 with DBBM significantly enhanced bone regeneration in a rat calvarial critical-sized defect model, with QG3030 demonstrating distinct osteogenic effects both in vitro and in vivo. Accordingly, the combination of QG3030 and DBBM represents a promising therapeutic approach for bone regeneration strategies, especially in periodontology and implant dentistry, and warrants further investigation.
• Effects of composition, finishing, and salivary pH on physicomechanical and biological properties of additively manufactured resin-ceramic composites: An in vitro study 2026.02.06
  CONCLUSION: CT showed superior physicomechanical properties. In acidic saliva, all AM RCs showed lower OD after glazing, whereas BA increased regardless of composition or finishing.
• Combined Effects of Zinc Compounds and Xylitol on the Enzymatic and Anticandidal Activities of Salivary Antimicrobials 2026.02.05
  CONCLUSIONS: Zinc compounds combined with xylitol increased lysozyme activity but reduced peroxidase activity. The combination synergistically increased the fungicidal activities of HEWL and the peroxidase system.
• Application of adipose-derived mesenchymal stem cell 3D structure, Microblock, as a skin regeneration therapy 2026.02.05
  Adipose-derived mesenchymal stem cells (Ad-MSCs) have been widely studied for their regenerative potential in skin wound healing due to their ability to modulate inflammation, regulate immune responses, promote angiogenesis, and facilitate extracellular matrix (ECM) remodeling. However, the therapeutic efficacy of single-cell transplantation is often limited by low engraftment efficiency and transient effects, restricting its long-term […]