Recent Publications

• Clinical and patient-reported outcomes of implant-retained overdentures fabricated by digital and conventional workflows: A systematic review of clinical studies 2025.11.29
  CONCLUSIONS: CAD-CAM IODs were found to have overall superior clinical performance and similar or better patient-related outcomes when compared with conventional ones.
• Oral health-related quality of life in oral cancer patients assessed with EORTC instruments: a scoping review 2025.11.29
  No abstract
• Biofilm comes back: Controlling regrowth by mitigating the cell-matrix interaction 2025.11.28
  Biofilms wield a notorious impact on biological infections and environmental sanitation in daily life. Tremendous efforts have been made to develop antimicrobial agents that effectively kill bacterial cells, but preventing biofilm reformation remains unsolved. For instance, a hydrogen peroxide (H(2)O(2)) and peracetic acid (PAA) mixture can inactivate almost 100 % of Pseudomonas aeruginosa cells in […]
• Comparison of 2D, 2.5D, and 3D landmark localization networks for 3D cephalometry in CT images 2025.11.27
  CONCLUSIONS: Comprehensive experiments demonstrate that the 2.5D network offers an optimal trade-off between computational load and accuracy. These findings highlight the potential for more efficient and reliable 3D cephalometry under limited computational resources.
• Optimized 3D-Printed Polylactic Acid/Graphene Oxide Scaffolds for Enhanced Bone Regeneration 2025.11.27
  CONCLUSIONS: This stepwise strategy-from structural design to pore size screening and preclinical validation-demonstrates that threshold-level mechanical properties can influence osteogenesis. PLA/GO scaffolds optimized at 558 μm and 562 μm provide a translationally relevant balance between mechanical stability and biological performance for bone tissue engineering.
• Optical Coherence Tomography for Assessing the Severity of Dental Caries: An In Vitro Validation Study 2025.11.26
  Background/Objectives: Differentiating initial from moderate non-cavitated occlusal caries using intraoral radiography is challenging. This in vitro study aimed to verify the ability of Optical Coherence Tomography (OCT) to discern the extent of demineralization in non-cavitated carious lesions and discriminate between the exact caries stages. Methods: In total, 110 extracted molars and premolars with occlusal caries […]
• Dhx36 deficiency accelerates BMSC senescence and promotes age-related bone loss 2025.11.23
  Senescence of mesenchymal stem cells in bone tissue (BMSCs), the primary progenitors of osteoblasts, is a key contributor to age-related osteopenia and osteoporosis. Aged cells exhibit elevated cellular stress and abnormal accumulation of stress granules (SGs), which contain G-quadruplex (G4) structured nucleic acids and G4-binding proteins. Dhx36, a helicase that unwinds G4 structure, may play […]
• Efficacy of topical application of zinc compounds for oral mucosal diseases: A systematic review and meta-analysis 2025.11.22
  CONCLUSIONS: Topical zinc therapy has promising efficacy in managing oral mucosal diseases, particularly in cancer therapy-induced oral mucositis. However, evidence for other conditions remains limited. Further comprehensive RCTs are needed to establish its effectiveness across various oral mucosal diseases.
• Clinical and demographic features of patients with occlusal dysesthesia: a retrospective cross‑sectional study 2025.11.22
  CONCLUSIONS: In this consecutive cohort, female sex and midlife age are independently associated with OD presentation. Although causality cannot be inferred, these findings may support the use of conservative, communication-focused management at the first presentation.
• Biomechanical properties of 3D-printed resin composites compared with subtractive CAD/CAM materials and direct light-cured composites: Color stability 2025.11.21
  OBJECTIVES: This study aimed to evaluate the color stability of four three-dimensionally-printed (3D) resin composites, and compare them with nine other commonly used subtractive computer-aided designing/computer-aided manufacturing (CAD/CAM) materials and resin composites for direct restoration.
• Diagnostic challenge in Burkitt lymphoma of the mandible initially misdiagnosed as osteomyelitis: a case report 2025.11.20
  Burkitt lymphoma (BL) is a highly aggressive B-cell neoplasm that rarely involves the mandible in elderly without apparent immunodeficiency. We report a case of a 72-year-old male who presented with persistent mandibular pain following extraction of tooth #46. Initial imaging findings were consistent with incipient osteomyelitis, and the patient was treated with antibiotics. Despite treatment, […]
• Printing accuracy and post-mounting dimensional stability of 3D-printed hollow dental models with varying shell thicknesses and cross-arch bars 2025.11.16
  CONCLUSIONS: Shell thickness and reinforcement significantly affected the trueness and stability of 3D-printed hollow dental models. Thicker shells with a cross-arch bar demonstrated the highest accuracy and stability, supporting their use in prosthodontic applications requiring articulator mounting.
• The effects of fabrication methods and build orientation on Candida albicans adhesion on 3D-printed and conventional denture resin: an in vitro comparative study 2025.11.16
  CONCLUSION: Microbial adhesion is significantly affected by fabrication methods and build orientation. Milled and 0-degree 3D printed resins provide improved options with the potential to minimize Candida albicans adhesion with the lowest surface roughness. Due to their high surface roughness and microbial adhesion, 3D-printed resins with different printing orientations require meticulous polishing and regular cleansing. […]
• CASKIN2 mediates PTPσ-orchestrated transsynaptic mechanisms at excitatory synapses 2025.11.12
  Presynaptic active zones (AZs) perform essential functions in orchestrating speedy and accurate neurotransmission. Despite extensive studies on their molecular constituents, it remains unclear how transsynaptic signals are organized at AZs. The two members of the CASKIN family of multidomain scaffold proteins, CASKIN1 and CASKIN2, bind to several AZ proteins and LAR receptor protein tyrosine phosphatases […]
• A novel cross-attentive network for classifying cervical metastatic lymph nodes on B- and D-mode ultrasound images in oral squamous cell carcinoma 2025.11.09
  CONCLUSION: LNM-Net demonstrates strong potential as a clinical decision-support tool for preoperative lymph node metastasis assessment in oral squamous cell carcinoma. Despite current limitations such as dataset size and cross-institutional variability, the model offers a promising supplementary aid, particularly in settings with limited radiological expertise.
• Concomitant Headache and Its Association With Worse Psychological and Clinical Status in Temporomandibular Disorders 2025.11.08
  CONCLUSIONS: TMD patients when reporting concomitant headache showed higher pain levels, widespread pain, and higher levels of psychological distress. The results indicate the need to appropriately address the issue of headache in TMD patients with an emphasis on psychological issues to improve overall prognosis.
• Factors affecting the fit of metal‑based restorations fabricated by selective laser melting: A systematic review 2025.11.08
  CONCLUSIONS: Within the limitations of current evidence, clinically acceptable fit was associated with cobalt chromium alloys printed at 0 or 30 degrees with a 25- to 50-µm layer thickness and optimized laser parameters. In contrast, a 90-degree printing orientation often resulted in marginal gaps exceeding acceptable thresholds.
• Research Trends in Medical and Dental Education (2015-2024) Based on Author Keywords: Commonalities, Differences, and Opportunities for Collaboration 2025.11.07
  CONCLUSION: This study identifies both foundational commonalities and discipline-specific innovations in medical and dental education research over the past decade. These findings suggest that shared interests and distinctive priorities can lead to meaningful opportunities for collaborative educational development and joint research efforts across health professions education.
• TUSC3 regulates ERMA-mediated Mg²⁺ uptake for synaptic function and neurodevelopment 2025.11.07
  Intellectual disability (ID) is characterized by deficits in cognition and adaptive behavior, with few treatment options. Tumor Suppressor Candidate 3 (TUSC3) has been genetically linked to autosomal recessive ID, but its molecular mechanism and therapeutic potential remain unclear. Here we show that TUSC3 is essential for endoplasmic reticulum (ER) Mg²⁺ homeostasis and neuronal function. Using […]
• Glioblastoma Immunotherapy Adjuvants for Glial Cell Polarization Regulation 2025.11.04
  Glioblastoma (GBM) remains fatal despite maximal surgical resection, temozolomide chemotherapy, and radiotherapy. Within the GBM microenvironment, tumor-educated microglia and astrocytes adopt immunoregulatory-like STAT3-high and ARG1/TGF-β-high phenotypes, respectively, which shield GBM cells from adaptive immune attack. In this review, we examine emerging adjuvant strategies designed to molecularly reprogram glial cells toward pro-inflammatory C3-high and IFN/NF-κB-high states, […]