Recent Publications

• Prediction and risk factor analysis of dental implant failure using Cox regression and machine learning 2026.02.28
  CONCLUSIONS: RSF showed good, but not superior, predictive accuracy compared with the best-performing Cox model. The choice of analytical method for implant survival studies should consider model complexity in relation to the dataset's sample size and event rate.
• Peri-implantitis as a potential risk factor for peri-implant oral malignancy 2026.02.27
  Peri-implant oral malignancy (PIOM) refers to malignant tumors arising around dental implants and is an increasingly reported complication of implant therapy. PIOM may follow distinct pathophysiological mechanisms, including chronic peri-implant inflammation and implant-related factors that contribute to carcinogenesis. This current review aims to explore the potential role of peri-implantitis (PI) as a risk factor for […]
• Three-dimensional evaluation of soft tissue contour changes after premolar extraction with and without alveolar ridge preservation: A prospective observational study 2026.02.27
  CONCLUSIONS: Intraoral scanning combined with digital superimposition proved effective for evaluating soft tissue changes after extraction. While ARP remains a valuable approach for alveolar bone preservation, its additional impact on soft tissue contour was limited in sites with favorable baseline conditions.
• Structure-Property-Function Evaluation of a β-Type Ti-Nb-Zr Alloy for Dental Implant Applications with Short-Term Clinical Validation 2026.02.26
  Titanium-based alloys are widely used in dental implantology; however, the mechanical limitations of commercially pure titanium (cpTi) and unresolved concerns regarding stress shielding remain. This study evaluated the structure-property-function relationship of a novel β-type titanium-niobium-zirconium (Ti-Nb-Zr; TNZ) alloy for dental implant applications. Laboratory testing assessed the elemental composition, tensile properties, and fatigue resistance of the […]
• Dimensional accuracy and internal fit of anterior 3-unit fixed dental prostheses fabricated by additive and subtractive manufacturing using polymer-based and ceramic restorative materials 2026.02.22
  CONCLUSIONS: AM-UA exhibited significantly higher dimensional accuracy at the internal and marginal regions of the anterior 3-unit FDPs compared with SM-GP. Although SM-HP showed the best internal fit and AM-UA exhibited the poorest, the internal fit of all tested FDPs was close to or below clinically acceptable thresholds.
• Integrating Oral Health into Primary Health Care for Refugees: A Content Analysis of Health Strategies of International Refugee Health Organizations 2026.02.20
  No abstract
• Supportive Periodontal Therapy Improves Implant Survival in Patients With a History of Periodontitis: A Retrospective Multicenter Cohort Study of 3555 Implants 2026.02.15
  CONCLUSION: Bone-level internal connection SA implants demonstrated favorable long-term survival. However, periodontitis-related tooth loss, GBR, and SPT compliance significantly affected implant longevity, emphasizing individualized risk assessment and continuous maintenance care. The absence of longitudinal radiographic bone-level data limits further evaluation of peri-implant bone stability.
• Acquisition of amantadine resistance via M gene reassortment in canine H3N2 influenza virus and elucidation of the resistance mechanism 2026.02.14
  A novel variant of the canine influenza virus H3N2 (cH3N2), designated as the M variant, was identified as containing a matrix (M) gene segment derived from the 2009 pandemic H1N1 virus (pdmH1N1), raising concerns regarding potential changes in antiviral drug sensitivity. In vitro and in vivo antiviral susceptibility assays demonstrated that while the parental cH3N2 […]
• Xerostomia in Patients With and Without Concomitant Oral Burning Pain And/Or Dysesthesia 2026.02.14
  CONCLUSION: The severity of xerostomia in patients with xerostomia alone is closely linked to salivary gland function, whereas in patients with xerostomia and concomitant oral burning pain and/or dysesthesia, it is more strongly influenced by the severity of these symptoms and psychological distress.
• Bone regenerative capacity of the newly synthesized material QG3030: an <em>in vitro</em> and <em>in vivo</em> study 2026.02.10
  CONCLUSIONS: Combining QG3030 with DBBM significantly enhanced bone regeneration in a rat calvarial critical-sized defect model, with QG3030 demonstrating distinct osteogenic effects both in vitro and in vivo. Accordingly, the combination of QG3030 and DBBM represents a promising therapeutic approach for bone regeneration strategies, especially in periodontology and implant dentistry, and warrants further investigation.
• Effects of composition, finishing, and salivary pH on physicomechanical and biological properties of additively manufactured resin-ceramic composites: An in vitro study 2026.02.06
  CONCLUSION: CT showed superior physicomechanical properties. In acidic saliva, all AM RCs showed lower OD after glazing, whereas BA increased regardless of composition or finishing.
• Combined Effects of Zinc Compounds and Xylitol on the Enzymatic and Anticandidal Activities of Salivary Antimicrobials 2026.02.05
  CONCLUSIONS: Zinc compounds combined with xylitol increased lysozyme activity but reduced peroxidase activity. The combination synergistically increased the fungicidal activities of HEWL and the peroxidase system.
• Application of adipose-derived mesenchymal stem cell 3D structure, Microblock, as a skin regeneration therapy 2026.02.05
  Adipose-derived mesenchymal stem cells (Ad-MSCs) have been widely studied for their regenerative potential in skin wound healing due to their ability to modulate inflammation, regulate immune responses, promote angiogenesis, and facilitate extracellular matrix (ECM) remodeling. However, the therapeutic efficacy of single-cell transplantation is often limited by low engraftment efficiency and transient effects, restricting its long-term […]
• Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic-Like Behaviors 2026.02.04
  Defensive behaviors against threatening situations are crucial for survival, and maladaptation of neural functions involved in defensive behavior may result in panic-like behavior. Defensive behaviors must be optimized for animals to efficiently avoid danger and maximize their chance of survival. The midbrain periaqueductal gray (PAG) controls defensive behaviors. However, the substrate of dysregulated panic-like defensive […]
• Injectable hyaluronic acid-based hydrogels with carbon dots and an iron complex for embolization 2026.02.04
  Although transarterial chemoembolization is a prevalent treatment for hepatocellular carcinoma (HCC), its efficacy is limited by inadequate vascular infiltration, inconsistent embolization, and lack of therapeutic synergy. We developed a multifunctional injectable hydrogel system using strategically combined high- and low-molecular-weight hyaluronic acid and a carbon dot/iron complex (APIO/Fe complex) to overcome these challenges. The dual-molecular-weight approach […]
• A Multifunctional β-Defensin-3 Mimetic Peptide Modulates Host-Biofilm Interactions and Reduces Bone Loss in Periodontitis 2026.02.03
  CONCLUSION: BDMP exhibited sustained antimicrobial and anti-inflammatory activity and attenuated bone loss in a beagle periodontitis model when used alongside standard SI therapy. These findings support BDMP as a promising adjunctive therapeutic candidate for managing periodontal inflammation and biofilm-associated disease, although further studies are needed to confirm long-term safety and to define its mechanistic contributions […]
• Intranasal vaccines adjuvanted with Nexavant demonstrate robust protective efficacy by inducing both mucosal and systemic immunity in a murine model 2026.02.02
  Mucosal vaccines offer the advantage of inducing immunity at pathogen entry sites; however, concerns about safety and limited efficacy have hindered the widespread use of viral-vectored intranasal vaccines. Nexavant (NVT), a well-defined TLR3 agonist, was investigated as a non-viral mucosal adjuvant. NVT was formulated with commercial subunit and polysaccharide-protein conjugate antigens and administered intranasally to […]
• Resource profiles and suicide attempts in youth with disabilities 2026.01.30
  CONCLUSIONS: The study highlights the heterogeneity of youth with disabilities, demonstrating how demographic characteristics, disability-specific needs, family and school environments and social support systems intersect to influence suicide attempt prevention.
• Efficacy of prolotherapy in temporomandibular joint disorders with hypertonic dextrose and Polydeoxyribonucleotide (PDRN) 2026.01.29
  CONCLUSIONS: Prolotherapy is an effective intervention for improving pain and jaw function in TMD patients. Both hypertonic dextrose and PDRN demonstrated significant clinical improvements on TMD prolotherapy.
• Figure-ground relationship of voices in musical structure modulates reciprocal frontotemporal connectivity 2026.01.29
  When listening to polyphonic music, we often perceive a melody as the figure against the ground of accompanying sounds. However, with repeated exposure, this figure-ground relationship may naturally shift, allowing the melody to recede into the ground. In a previous study, we found the consistent pattern of frontotemporal connectivity for the "Twinkle, Twinkle, Little Star" […]