Recent Publications

• Biomimetic Catechol-Incorporated Polyacrylonitrile Nanofiber Scaffolds for Tissue Engineering of Functional Salivary Glands 2025.07.03
  Replacing damaged salivary glands with in vitro-generated artificial glands offers a fundamental solution for salivary gland dysfunction. However, this approach remains challenging due to the gland's complex structure and cellular heterogeneity. Since natural organogenesis of salivary glands successfully orchestrates these complex processes, replicating the developmental niche in vitro is considered a promising solution. However, it […]
• Mitigation of radiation-induced esophageal fibrosis by macrophage-targeted phosphatidylserine-containing liposomes with partial PEGylation 2025.07.03
  Radiation-induced fibrosis (RIF) is a major complication following radiotherapy treatment. Macrophages are the key regulators of inflammatory responses and have emerged as critical targets for the prevention of fibrosis. This study evaluated the efficacy of PEGylated phosphatidylserine-containing liposomes (PEG-PSLs) in mitigating RIF by modulating macrophage activity. PEG-PSLs influenced the polarization of bone marrow-derived macrophages (BMDMs), […]
• Surgical Accuracy of Maxillomandibular Clockwise Rotation Using Computer-Aided Surgical Planning in Skeletal Class III Patients 2025.07.03
  This retrospective study aimed to evaluate the 3-dimensional (3D) surgical accuracy by comparing the virtual movements of computer-aided surgical planning (CASP) with the outcomes of actual surgery (AS) in class III patients treated with clockwise rotation of the maxillomandibular complex. Twenty adult patients with skeletal class III malocclusion were included, all of whom received bimaxillary […]
• An epidemiological trend analysis of oral cancer in Korea from 2001 to 2021 2025.07.02
  CONCLUSIONS: These findings demonstrate distinct epidemiological shifts in oral cancer in Korea over the past two decades, particularly by age, sex, and anatomical subsite. While incidence increased notably among younger females, mortality declined in males, suggesting improved survival outcomes. These results underscore the importance of continuous monitoring and subsite-specific prevention strategies tailored to evolving demographic […]
• A comparative evaluation of chain-of-thought-based prompt engineering techniques for medical question answering 2025.07.02
  CONCLUSION: Complex prompting techniques do not significantly enhance performance compared to simpler approaches. Dataset characteristics and model architecture have greater impact, suggesting simpler CoT methods may be more effective for clinical applications.
• A deep and multi-helix flute threaded implant: a review and clinical analysis 2025.07.01
  CONCLUSION: We need to determine appropriate designs for implants with the consideration of bone quality and implantation bed condition.
• Treatment of non-chronic odontogenic sinusitis: maxillary sinus lavage via extraction socket after tooth or implant removal 2025.07.01
  CONCLUSION: Treating non-chronic odontogenic maxillary sinusitis through sinus irrigation via the extraction site, combined with appropriate antibiotic therapy, was effective in resolving symptoms and avoiding additional surgeries.
• Facial Asymmetry Phenotypes in Adult Patients With Bilateral Cleft Lip and Palate and Skeletal Class III Malocclusion Using Principal Component Analysis and Cluster Analysis 2025.07.01
  CONCLUSION: This FA phenotype classification could serve as a guideline for diagnosis and OGS planning for BCLP patients.
• Investigation of Proteome-Tetrazine Reactivity for a Highly Selective Tetrazine Ligation in Live Cells 2025.06.30
  Tetrazine has been widely used in bio-orthogonal click chemistry for diverse biological applications due to its short reaction time and excellent bio-orthogonality. For efficient click reaction, the stability of tetrazine in physiological conditions is one of the key issues in biological applications. However, the reactions between tetrazine and biomolecules have barely been studied. Here, we […]
• Dimensional analysis of condylar head using 3D scanned models of human dry skulls: A comparative study of measurement methods 2025.06.25
  CONCLUSION: Measurements of the condylar head should be taken from the outermost points. Given the nature of bone remodeling, relying solely on a single cut from CBCT images for dimensional evaluation may result in missing potentially significant changes.
• Long-term evaluation of progressive condylar resorption after orthognathic surgery in mandibular retrognathism with high mandibular plane angle: An analysis of three-dimensional computed tomography 2025.06.23
  INTRODUCTION: The purposes of this study were to analyze the volumetric change of condyle in postoperative progressive condylar resorption (PCR) using three-dimensional computed tomography (3D CT) over a long-term follow-up period of at least 2 years after mandibular advancement surgery, and the correlation between changes in the condylar volume in 3D CT and the condylar […]
• <em>In vitro</em> assessment of BBI608 in 2D and 3D culture models for drug repositioning in oral squamous cell carcinoma 2025.06.20
  STAT3 is abnormally activated in several types of cancer, and elevated nuclear levels of STAT3 are strongly associated with poor prognosis in oral squamous cell carcinoma (OSCC). Despite ongoing progress in developing targeted therapies, there is no Food and Drug Administration‑approved drug currently targeting STAT3 in OSCC. To evaluate the anticancer effects of BBI608, a […]
• Research Waste in Temporomandibular Disorders Among Registered Randomised Controlled Trials: A Meta-Epidemiologic Study 2025.06.18
  CONCLUSION: Future research should emphasise clinician training in TMDs subdiagnosis and adopt feasibility-driven trial designs, including comprehensive assessments of recruitment capacity and intervention feasibility. Addressing these factors may optimise RCTs quality and reduce research waste.
• Mechanotransduction-enhanced bioconstructs fabricated using a bioink comprising collagen and omega-3 fatty acids for gingival tissue regeneration 2025.06.16
  Rationale: Tissue engineering through three-dimensional (3D) bioprinting has emerged as a highly promising strategy for creating custom-designed 3D bioconstructs that closely mimic native tissue architecture. However, ongoing advancements in bioink formulation and bioprinting processes are required to achieve precise replication of target tissues. In particular, effective vascularization and extracellular remodeling are essential for successful gingival […]
• Differences in morphologies of the articular eminence and glenoid fossa according to disk displacement and sex 2025.06.13
  CONCLUSION: The joints with DDNR have greater length and volume of the glenoid fossa, greater eminence height, and smaller eminence inclination compared to those with NR, regardless of sex.
• Establishing cut-off values for salivary MMP-8 and IL-1β in the diagnosis of active periodontal disease: a preliminary cohort study toward the development of a diagnostic kit 2025.06.12
  CONCLUSIONS: Our findings indicate that salivary MMP-8, using a cut-off value of 200 ng/mL, serves as a reliable biomarker for identifying active periodontal disease. This biomarker holds potential for further development into a diagnostic tool in in vitro settings, which could improve the early detection and management of periodontal disease.
• Baricitinib-loaded separable microneedle array patch (S-MAP) based on hyaluronic acid for alopecia areata therapy 2025.06.08
  Separable and dissolvable microneedle array patch based primarily on hyaluronic acid is designed for the topical delivery of baricitinib in alopecia areata (AA) therapy. Locoregional application of a separable microneedle array patch (S-MAP) may avoid the systemic side effects of oral administration and can be administered without pain compared with typical intradermal injections. Baricitinib (which […]
• Dental anxiety among students in Indonesia: the role of demographic, behavioral, social, and spiritual support 2025.06.04
  CONCLUSIONS: Dental anxiety among students in Indonesia was significantly associated with the demographic (fields of study), behaviors (frequency of toothbrushing, reason for the last dental visit, past dental experience, SROH), social support (from friends) and spiritual support. Although the proposed SEM model accounted for 15% of the variance in DA, further studies are needed to […]
• Mandible-Only Orthognathic Surgery Achieves Higher Accuracy Than Bimaxillary Surgery for Skeletal Class III Malocclusion 2025.06.03
  A previous study analyzing the accuracy of bimaxillary orthognathic surgery for class III malocclusion revealed its accuracy is lower in the mandible than in the maxilla. This raised the question of whether the discrepancy is due to inherent mandibular inaccuracy or is influenced by maxillary discrepancy. Although numerous studies have examined the indications, stability, and […]
• Functional and distinct roles of Piezo2-mediated mechanotransduction in dental primary afferent neurons 2025.06.03
  Piezo2, a mechanosensitive ion channel, serves as a crucial mechanotransducer in dental primary afferent (DPA) neurons and is potentially involved in hypersensitivity to mild mechanical irritations observed in dental patients. Given Piezo2's widespread expression across diverse subpopulations of DPA neurons, this study aimed to characterize the mechanosensory properties of Piezo2-expressing DPA neurons with a focus […]