Recent Publications

• Polydeoxyribonucleotide (PDRN) in Dentistry: Narrative Review for Mechanisms and Emerging Clinical Applications 2026.01.17
  CONCLUSION: Although these findings highlight broad therapeutic potential, current evidence remains limited. Most reports derive from preclinical experiments or small-scale clinical studies, and well-designed randomized controlled trials are needed to validate efficacy of PDRN and define its optimal clinical indications in evidence-based dental protocols.
• <em>Panax ginseng</em>-derived Exosome-like Nanoparticles Prevent LPS-induced Septic Shock by Modulating TLR4 Glycosylation in Macrophages 2026.01.13
  Macrophages play a crucial role in the pathophysiology of sepsis, serving as central regulators of both disease onset and progression. Among the therapeutic agents investigated to modulate macrophage-driven inflammation, compounds extracted from the roots of Panax ginseng have been distinguished for their potent anti-inflammatory properties. Recently, attention has shifted toward ginseng-derived exosome-like nanoparticles (GDEs) because […]
• Biofluorescence imaging-guided implantoplasty for the management of peri-implantitis: a retrospective case series 2026.01.13
  No abstract
• Neuropathy of the infraorbital area following rapid palatal expansion: A case report 2026.01.10
  RATIONALE: Neuropathic pain in the orofacial region, although relatively uncommon, can occur after dental procedures performed in trigeminally innervated areas. Miniscrew-assisted rapid palatal expansion (MARPE) is widely adopted to correct maxillary transverse deficiency in adults and is generally safe; however, neurosensory complications are rarely documented. This case highlights infraorbital neuropathy following MARPE, underscoring the need […]
• Professional values of dentists in the Republic of Korea: Influence of clinical experience and competitive pressure 2026.01.09
  CONCLUSIONS: Dentists' professional values are dynamic and context-dependent, evolving with career stage while retaining stable core elements of professionalism. Understanding these dynamics requires a life course perspective that accounts for practice environments.
• Identification of predictors for bone regeneration at the distal aspect of the second molar after impacted mandibular third-molar extraction 2026.01.09
  CONCLUSIONS: These findings emphasize the limited natural recovery of alveolar bone and the importance of initial defect depth, ramus class, and age in predicting outcomes and optimizing postoperative management.
• Two-stage deep learning approach for screening for anterior disk displacement of the temporomandibular joint using orthopantomograms 2026.01.07
  No abstract
• Understanding of the different roles of Noggin in the Noggin-BMP-2 and Noggin-BMP-9 dimer complexes at the molecular level 2026.01.04
  Bone morphogenetic proteins (BMPs) play crucial roles in tissue development and repair as growth factors. However, the clinical application of some type of BMPs is restricted due to their undefined and uncontrolled complex signaling pathways. This study investigates the interactions of BMPs, particularly BMP-2 and BMP-9, with Noggin, a BMP antagonist crucial for embryonic development. […]
• Oral microbiome-based evaluation of periodontal treatment responses in individuals with special health care needs: a longitudinal study 2026.01.04
  No abstract
• Orally Administered Nanoparticle Coacervate for Therapeutic Coating of Full Gastrointestinal Tract 2026.01.03
  Oral delivery of therapeutic nanoparticles offers a non-invasive approach for treating gastrointestinal diseases, but achieving localized and sustained mucosal exposure while avoiding systemic toxicity remains a major challenge. Here, a Sucralfate-based oral formulation is developed that incorporates therapeutic nanoparticles and transforms into a paste-like coacervate upon contact with intestinal fluid, uniformly coating the entire gastrointestinal […]
• Does Temporomandibular Joint Disc Displacement Influence Joint Space Dimensions, and Does Sex Play a Role? 2026.01.02
  CONCLUSIONS AND RELEVANCE: DD is associated with smaller condyles and enlarged fossa, contributing to increased anterior joint space dimensions. These findings may aid diagnosis and treatment planning in patients with TMJ DD.
• Drosophila Abi maintains blood cell homeostasis by promoting clathrin-mediated endocytosis of Notch 2025.12.31
  Abl-interactor (Abi) proteins induce actin polymerization by activating Wiskott-Aldrich syndrome protein (WASp) or SCAR/WASP-family verprolin-homologous protein. Loss of mammalian Abi1 causes myeloproliferative neoplasm; however, little is known about how the Abi family of actin-regulatory proteins regulates blood cell homeostasis. Here, we demonstrate that Drosophila Abi promotes plasmatocyte-to-crystal cell transdifferentiation but represses plasmatocyte-to-lamellocyte transdifferentiation...
• Biomimetic Salivary Gland Cancer Spheroid Platform for In Vitro Recapitulation of Three-Dimensional Tumor-Stromal Interactions 2025.12.30
  Salivary gland carcinomas (SGCs) are aggressive malignancies with limited treatment options, primarily due to the complexity of the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) remodel the extracellular matrix (ECM), enhance cancer cell stemness, and drive drug resistance. This study introduces a decellularized CAF-derived spheroid system as a biomimetic platform to study tumor-stromal interactions in SGC. […]
• Dammarenediol II enhances etoposide-induced apoptosis by targeting O-GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer 2025.12.30
  Combining chemotherapy with chemosensitizing agents is a common strategy to enhance anticancer efficacy while mitigating treatment-related side effects. This study investigated the potential of dammarenediol II (DM2), a ginsenoside precursor, to enhance the anticancer effects of etoposide by downregulating O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) and modulating the Akt signaling pathway in HepG2 human liver cancer cells. […]
• Medication-related osteonecrosis of the jaw: an evidence-based 2025 position statement from a Korean multidisciplinary task force 2025.12.30
  With a rapidly aging population and increasing use of antiresorptive agents, medication-related osteonecrosis of the jaw (MRONJ) represents a growing clinical challenge worldwide. To address the need for tailored clinical guidance, a multidisciplinary task force was convened. Five Korean academic societies-the Korean Society for Bone and Mineral Research, the Korean Association of Oral and Maxillofacial […]
• NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons 2025.12.30
  No abstract
• Prolotherapy for temporomandibular joint disorders: an updated comprehensive review 2025.12.30
  Temporomandibular joint disorders (TMDs) comprise multifactorial conditions involving pain, joint noises, and restricted mandibular motion. Prolotherapy, involving intra-articular or periarticular injection of proliferative agents such as hypertonic dextrose or polydeoxyribonucleotide (PDRN), has recently gained attention as a regenerative therapy for refractory TMDs. This review summarizes current evidence and biological mechanisms underlying prolotherapy in temporomandibular joint […]
• Feasibility of a Modified Island Groin Flap for Microsurgical Training: An Experimental Study 2025.12.24
  CONCLUSION: The modified groin flap is easy to recreate in a rat model and well-suited for microsurgical training among novice trainees. This flap design also serves as a reliable platform for studying ischemic-reperfusion injury.
• Restoring Cell-Cell Junctions in DSPP-Deficient Odontoblasts Through Nanofibrous Topography and Wnt5a-Cdc42 Activation: A Laboratory Investigation 2025.12.24
  CONCLUSION: The results provide evidence that Dspp contributes to the structural integrity of dentine by modulating ZO-1 and Cx43 expression and suggest that biomaterial and molecular interventions may offer supportive strategies to restore dentine structure and function in DGI-affected teeth, though they do not address the underlying genetic defect.
• SARS-CoV-2 animal vaccine with cross-protection against Wuhan strain and delta variant 2025.12.23
  The increasing number of reverse zoonotic transmission cases, in which pathogens are transmitted from humans to companion animals, has raised substantial concerns in both veterinary and public health fields. The emergence of novel viral strains through interspecies transmission poses a potential threat to the health of animals and humans. In response to the growing incidence […]