Recent Publications

• First-In-Human Study of Safety, Tolerability, Efficacy, and Pharmacokinetics of CPNE7-Derived Peptide (Selcopintide) for Dentin Hypersensitivity 2025.08.19
  Dentin hypersensitivity is characterized by transient, sharp pain resulting from dentin exposure due to enamel or cementum loss. Current treatments, which primarily focus on superficial tubule occlusion or nerve desensitization, provide only temporary relief. Copine7 (CPNE7) induces odontoblast differentiation and physiologic dentin regeneration, enabling biological dentin sealing and presenting a novel therapeutic approach. This study […]
• Differential effects of 17β-estradiol on knee and temporomandibular joints in ovariectomized rats 2025.08.17
  This study aimed to investigate the therapeutic effects of different concentrations of 17β-estradiol (E2) on knee joints (KJ) and temporomandibular joints (TMJ) in ovariectomized rats, with a focus on bony changes and inflammation. Bilateral ovariectomy was performed to induce estrogen deficiency, and various concentrations of E2 were administered (0, 10, 50, or 100 μg/100 g […]
• The dimethyloxalylglycine-functionalized nanofibers for <em>in situ</em> regeneration of infected developing dental roots 2025.08.14
  In situ regeneration in restorative dentistry targets the repair of tissues directly at the injury site by utilizing engineered biomaterials to guide endogenous cell activity. This approach aims to simplify treatment procedures and achieve more predictable outcomes, thus to supports the regeneration of damaged tissues and potentially restores tooth vitality, reducing the need for more […]
• Diagnostic Performance of Quantitative Parameters Derived from Twin-Beam Dual-Energy CT for Differentiating Benign and Malignant Salivary Gland Tumors of the Palate 2025.08.14
  CONCLUSION: TB-DECT-derived parameters, especially IC, DEI, and λHU, may aid in differentiating malignant from benign palatal salivary gland tumors. Virtual monochromatic images at low keV levels can enhance discrimination between malignant and benign lesions.
• Korean and Chinese citizens' pandemic fatigue and related factors amidst the prolonged COVID-19 pandemic: Implications for risk communication 2025.08.13
  Pandemic fatigue has emerged as a significant public health challenge, particularly in countries that implemented prolonged COVID-19 public health and social measures (PHSM). Understanding the factors contributing to pandemic fatigue and its impact on adherence to health protective behaviors is essential for sustaining public engagement in long-term disease management. This study examines pandemic fatigue in […]
• Synergistic epigenetic modulation by 5-aza-2'-deoxycytidine and Wnt3a drives osteogenic trans-differentiation of 3T3-L1 pre-adipocytes through <em>Ywhah</em> and <em>Ywhae</em> 2025.08.12
  CONCLUSIONS: Combining 5azaC-induced demethylation with Wnt3a is a potent strategy to redirect pre-adipocytes toward osteogenesis. Identification of key targets like Ywhah and Ywhae provides mechanistic insight into trans-differentiation and suggests therapeutic potential for bone regeneration, particularly in elderly periodontal patients.
• Evaluation of dental implant with hydroxyapatite coating by laser-induced hydrothermal synthesis: in vitro and in vivo experimental study 2025.08.12
  Various surface modification techniques have been developed to improve the survival rate of dental implants. This study aimed to evaluate both in vitro and in vivo outcomes of implants coated with a nano/micro-assembled hydroxyapatite (HA) structure using a laser-induced single-step coating (LISSC) technique. Four types of implant surfaces were examined: machined surface implants (MA), sandblasted […]
• Organoid-based modeling and regenerative strategies for salivary gland dysfunction 2025.08.08
  Xerostomia, a pathological condition resulting from hyposalivation due to salivary gland (SG) dysfunction, severely affects a patient's health, quality of life, and healthcare costs. Despite its high prevalence, long-term curative treatments remain unavailable, leaving patients with lifelong symptom management. Permanent SG damage caused by disease or injury exacerbates this condition, highlighting the urgent need for […]
• Number of Teeth as a Predictor for Falls and Fractures in Community-Dwelling Older Adults 2025.08.08
  CONCLUSIONS: Having fewer than five dentitions in older adults is a significant predictor of falls and fall-related fractures over 4 years.
• Pyrimethamine Triggers the Apoptotic Pathway in Mucoepidermoid Carcinoma in Cell-Based Models 2025.08.06
  CONCLUSION: Our results indicate that PYR can effectively target human MEC by inducing both intrinsic and extrinsic apoptotic pathways.
• Comparative analysis of fit, mechanical properties, and surface characteristics in subtractive- and additive-manufactured zirconia crowns 2025.08.01
  CONCLUSIONS: Zirconia crowns produced through the AM and SM methods demonstrated clinically acceptable marginal fit and ideal hardness exceeding 1200 HV. Some AM groups demonstrated higher hardness and shear bond strength than the SM group. The diverse physical and mechanical properties of various zirconia AM technologies suggest their selective use in specific clinical situations. Certain […]
• DCrownFormer⁺: Morphology-aware mesh generation and refinement transformer for dental crown prosthesis from 3D scan data of preparation and antagonist teeth 2025.07.30
  Dental prostheses are important in designing artificial replacements to restore the function and appearance of teeth. However, designing a patient-specific dental prosthesis is still labor-intensive and depends on dental professionals with knowledge of oral anatomy and their experience. Also, this procedure is time-consuming because the initial tooth template for designing dental crowns is not personalized. […]
• Accuracy of Artificial Intelligence in Predicting the Treatment Effects of Headgear and/or Functional Appliance on the Maxillo-Mandibular Growth in Preadolescent Patients With Skeletal Class II Malocclusion 2025.07.25
  CONCLUSION: This study demonstrates the potential of AI to reliably predict the effects of HG and/or FA treatment in preadolescent patients with Class II malocclusion.
• Improved bone regeneration with bone targeted scaffold 2025.07.24
  The sustained release and bone tissue-specific localization of bone morphogenetic protein 2 (BMP-2) are crucial factors in overcoming the shortcomings in its clinical use. In a previous study, we introduced a bone-targeted, lipoplex-loaded, three-dimensional (3D) bioprinted bilayer scaffold, termed polycaprolactone-bioink-nanoparticle (PBN). We confirmed the bone-specific and sustained release of BMP-2 with PBN in silico and […]
• Rapid-Turnaround Co-Administration of mRNA-Based MHC-I and MHC-II-Restricted Neoantigens Enhances Immune Responses of Antigen-Specific CD8⁺ T Cells and Anti-Cancer Efficacy in Colorectal Cancer 2025.07.23
  Personalized cancer vaccines (PCVs) represent a promising frontier in cancer immunotherapy; however, challenges in neoantigen prediction and treatment optimization persist. This study aims to introduce an innovative mRNA-based PCV platform that addresses these limitations. Co-administration of our major histocompatibility complex (MHC)-I and MHC-II-restricted neoantigens increases antigen-specific T cell responses and exhibits strong anti-cancer efficacy, significantly […]
• Chlorpromazine induces hyposalivation by inhibiting muscarinic Ca²⁺ signaling in salivary glands 2025.07.23
  Chlorpromazine (CPZ), a dopamine D2 receptor antagonist, is an antipsychotic drug widely used in the treatment of schizophrenia. While CPZ is known to induce hyposalivation, the exact mechanism by which it inhibits secretory function in the salivary glands remains unclear. In this study, we investigated the molecular mechanism underlying CPZ-induced hyposalivation. Our findings confirmed that […]
• <em>Daphne kiusiana</em> Crude Extract and Its Fraction Enhance Keratinocyte Migration via the ERK/MMP9 Pathway 2025.07.23
  Daphne kiusiana is a naturally occurring plant in East Asia belonging to the Thymelaeaceae family. While its biological properties have been explored, its potential role in wound healing remains largely unknown. This study investigated the effects of Daphne kiusiana extracts on keratinocyte migration and the underlying mechanisms. The crude extract and its fractions was tested […]
• Macrophage-associated biocompatibility of titanium revealed by analyzing foreign body reaction at bone-implant interface 2025.07.21
  CONCLUSION: The recruitment of M1 macrophages at the copper implantation site, but not at the titanium implant, indicates the FBR to copper and underlies the biocompatibility of titanium. Titanium may affect the differentiation of intrabony macrophages to increase its biocompatibility.
• Pink esthetic treatment of gingival recession, black triangle, and gummy smile: a narrative review 2025.07.17
  CONCLUSIONS: The use of these biomaterials in pink esthetic management enables clinicians to achieve favorable esthetic outcomes with reduced invasiveness. This approach minimizes the need for additional restorative or surgical interventions, thereby enhancing patient comfort and satisfaction.
• Impact of continued antithrombotic use on bleeding risk in oral surgery- a retrospectively study in a population patients treated in a Korean university hospital 2025.07.14
  CONCLUSION: Continuing antithrombotic therapy does not significantly increase the risk of postoperative bleeding in patients undergoing oral surgeries. Dental practitioners can consider maintaining antithrombotic therapy during certain procedures, emphasizing the importance of balancing bleeding risks with the potential for thromboembolic events.