1987-1992
Seoul National University
B.S. Micl Biorobiology
1994-1999
Ph.D. Department of Cell Biology (Neuroimmunology major)
University of Alabama at Birmingham
22000.2.-2000.9.
Post-doctoral fellow
Department of Cellogy, University of Alabama at Birmingham
2000.10.-2003.1.
Post-doctoral fellow
Department of Pharmacology, The University of California at San Diego
Full-time instructor
Department of Oral Physiology
College of Dentistry, Seoul National University
2005.4.-2009.3
Assistant Professor
Department of Oral Physiology
College of Dentistry, Seoul National University
2009.4. – 2014.3.
Associate Professor
Department of Neuroscience and Physiology
College of Dentistry, Seoul National University
2014.4 – present
Professor
Department of Neuroscience and Physiology
College of Dentistry, Seoul National University
1994-1999
Graduate Student, University of Alabama at Birmingham, Mentor: Dr. Etty N. Benveniste
: Transcriptional regulation and the function of ICAM-1 and Fas (CD95) expression in glial cells
1999-2000.9.
Post-doctoral Fellow, University of Alabama at Birmingham, Mentor: Dr. Etty N. Benveniste
: Cloning of ICAM-1 interacting protein using yeast two-hybrid system
2000.10.-2003.1.
Post-doctoral Fellow, University of California at San Diego, Mentor: Dr. Michael Karin
: Generation of glial cell-specific IKKβ and JNK1 conditional knock out mice; The role of glial cell-specific NF-κB or JNK activation in demyelinating and neurodegenerative diseases.
2003.2.1.-present
College of Dentistry, Seoul National University
: Role of TLR on glial cells in neurodegeneration and neuropathic pain; Toll-like receptors in itch; Role of glial cell activation in the CNS inflammatory diseases in vivo.
2007
Ad Hoc Member of Ireland Health Research Board
2010~present
Editorial Board Member of International Journal of Biological Chemistry
2012~Present
Editorial Board Member of Mol. Brain
2014~present
Editorial Board Member of the International Journal of Neurology Research
2018~present
Editorial Board Member of Experimental Neurobiology
2001-2003.1.
National Multiple Sclerosis Society Post-doctoral Fellowship
1. Kwon, J., Lee, S. J., and E. N. Benveniste. 1996. A 3’ cis-acting element is involved in TNF-α gene expression in astrocytes. J. Biol. Chem. 271: 22383-22390.
2. Shrikant, P., Lee, S. J., Kalvakolanu, I., Ransohoff, R. M., and E. N. Benveniste. 1996. Stimulus-specific inhibition of intercellular adhesion molecule-1 gene expression by TGF-β. J. Immunol. 157: 892-900.
3. Agrawal, A., Lee, S. J., Carson, M., Narayana, S. V. L., Greenhough, T. J., and J. E. Volanakis. 1997. Site-directed mutagenesis of the phosphocholine-binding site of human C-reactive protein. J. Immunol. 158: 345-350.
4. Goldsmith, J. F., Lee, S. J., Jiang, J., and S. J. Frank. 1997. Growth hormone induces detergent insolubility of GH receptors in IM-9 cells. Am. J. Physiol. 273: E932-E941.
5. Lee, S. J., Hou, J., and E. N. Benveniste. 1998. Transcriptional regulation of intercellular adhesion molecule-1 in astrocytes involves NF-κB and C/EBP isoforms. J. Neuroimmunol. 92: 196-207.
6. Lee, S. J., Park, J. Y., Hou, J., and E. N. Benveniste. 1999. Transcriptional regulation of the intercellular adhesion molecule-1 gene by proinflammatory cytokines in human astrocytes. GLIA. 25: 21-32.
7. Lee, S. J., and E. N. Benveniste. 1999. Adhesion molecule expression and regulation on cells of the central nervous system. J. Neuroimmunol. 98:77-88.
8. Lee, S. J., Zhou, T., Choi C., Wang, Z., and E. N. Benveniste. 2000. Differential regulation and function of Fas expression on glial cells. J. Immunol. 164:1277-1285.
9. Lee, S. J., Drabik, K., Van Wagoner, N. J., Lee, S., Choi, C., Dong, Y., and E. N. Benveniste. 2000. ICAM-1-induced expression of proinflammatory cytokines and chemokines in astrocytes: Involvement of ERK and p38 MAP kinases. J. Immunol. 165: 4658-4666.
10. Choi, C., Xu, X., Oh, J. W., Lee, S. J., Gillespie, G. Y., Park, H., Jo, H., and E. N. Benveniste. 2001. Fas- induced expression of chemokines in human glioma cells: Involvement of ERK1/ERK2 and p38 MAP kinases. Cancer Res. 61 (7): 3084-3091.
11. Lee, S. J., Drabik, K., E. N. Benveniste. 2001. Cloning of rat calcium-modulating cyclophilin ligand. DNA Seq. 12 (3): 209-213.
12. Lee, S. J. and S. Lee. 2002. Toll-like receptors and inflammation in the CNS. Current Drug Targets-Inflammation & Allergy. 1: 181-191.
13. Sim, M-Y., Yeon, K-Y., Choi, S-Y., Lee, S.J., Park, K., Lee, J., Oh, S.B., Kim. J-S. 2003. Modulation of calcium currents by nociceptin/orphanin FQ in trigeminal neurons. Int. J. Oral Biol., 28(2): 43-47. (Aug. 1.)
14. Kim, J.G., Lee S. J., and Kagnoff M.F. 2004. Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors. Infection & Immunity, 72(3): 1487-1495. (Mar. 1)
15. Lee, S., Hong, J., Choi, S., Oh, S. B., Park, K., Kim, J. S., Karin, M., S. J. Lee. 2004. CpG oligonucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-κB activation. J. Neuroimmunol. 153:50-63. (Aug. 1)
16. Lee, M.H., Yeon, K-Y., Fang, Z., Kim, M.S., Park, C-K., Choi, S-Y., Lee, S. J., Park, K., Lee, J-H., Oh, S.B., J.S. Kim. 2004. Differential effects of transient receptor potential vanilloid ligands on calcium currents. Int. J. Oral Biol., 29(3):93-98. (Sept. 30.)
17. Lee, H., Park, C., Choi, S., Oh, S. B., Park, K., Kim, J., S. J. Lee. 2004. Double-stranded RNA induces inflammatory gene expression in Schwann cells: Implication in the Wallerian degeneration. Korean J. Physiol. Pharmacol. 8:253-257. (Oct. 1)
18. Kyu-Young Yeon, Mi-Young Sim, Se-Young Choi, Sung Joong Lee, Kyungpyo Park, Joong Soo Kim, Jong-Heun Lee, Kyung-Mi Lee and Seog Bae Oh. 2004. Molecular Mechanisms Underlying Calcium Current Modulation By Nociceptin. Neuroreport. 15(14):2205-9. (Oct. 5)
19. Li, J., Ha, Y-M., Ku, N-Y, Choi, S-Y, Lee, S. J., Oh, S.B. Kim, J-S, Lee, J-H, Lee, E.B., Song, Y.W., Park, K., 2004. Inhibitory effects of autoantibodies on the muscarinic receptors in Sjogren’s syndrome. Lab. Invest. 84:1430-1438. (Nov. 1)
20. Bang, G-Y., Pioa, Z.G., Choi, S-Y., Lee, S. J., Park, K., Kim, J.S., S.B. Oh. 2004. Changes in expression of high-voltage-activated calcium channel in facial motoneurons following facial nerve injury. Int. J. Oral Biol., 29(4):127-132. (Dec. 31.)
21. Hyo-Chel Ryu, Zheng Gen Piao, Se-Young Choi, Sung Joong Lee, Kyungpyo Park, Joong Soo Kim, and Seog Bae Oh, 2005. ABAergic Synaptic Input to Mesencephalic Trigeminal Neurons in Rat. Int. J. Oral Biol., 30(2):71-76. (Jun. 30.)
22. Lee, MH, Yeon, K-Y, Park, C-K, Li, H-Y, Fang Z, Kim, MS, Choi, S-Y, Lee, S. J., Lee, S, Park K, Lee, J-H, Kim JS, S.B. Oh. 2005. Eugenol inhibits calcium currents in dental afferent neurons. J. Dent. Res. 84(9):848-851. (Sep. 1)
23. Park, DJ, Park, SA, Yoon, TG, Lee, S. J., Yum, KW, HJ Kim. 2005. Bupivacaine induces apoptosis via ROS in the Schwann cell line. J. Dent. Res. 84(9):852-857. (Sep. 1)
24. Park C, S Lee, I Cho, H Lee, D Kim, S-Y Choi, S B Oh, K Park, J S Kim, and Sung Joong Lee, 2006. A TLR3-mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: Differential signaling mechanisms of TLR3-induced IP-10 and IL-8 gene expression. GLIA. 53:248-256. (Feb.1)
25. Kim MS, Park CK, Yeon KY, Li HY, Jung SJ, Choi SY, Lee SJ, Park K, Kim JS, Oh SB. 2006. Involvement of transient receptor potential vanilloid-1 in calcium current inhibition by capsaicin. Neuroreport. 17(2):145-149. (Feb. 6)
26. Cho IH, Chung YM, Park CK, Park SH, Li HY, Kim D, Piao ZG, Choi SY, Lee SJ, Park K, Kim JS, Oh SB. 2006 Systemic administration of minocycline inhibits formalin-induced inflammatory pain in rat. Brain Res. 1072(1): 208-214. (Feb 9)
27. Piao ZG, Cho IH, Park CK, Hong JP, Choi SY, Lee SJ, Lee S, Park K, Kim JS, Oh SB. 2006. Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury. Pain. 121(3):219-31. (Apr. 1)
28. Koo NY, Li J, Hwang SM, Choi SY, Lee SJ, Oh SB, Kim JS, Lee JH, Park K. 2006. Molecular cloning and functional expression of a sodium bicarbonate cotransporter from guinea-pig parotid glands. Biochem. Biophys. Res. Commun. 342(4):1114-22. (Apr. 21).
29. Piao L, Ying Li H, Park CK, Cho IH, Piao ZG, Jung SJ, Choi SY, Lee SJ, Park K, Kim JS, Oh SB Mechanosensitivity of voltage-gated K(+) currents in rat trigeminal ganglion neurons. J. Neurosci. Res. 2006 May 15;83(7):1373-80.)
30. Park CK, Kim MS, Fang Z, Li HY, Jung SJ, Choi SY, Lee SJ, Park K, Kim JS, Oh SB. Functional expression of thermo-transient receptor potential channels in dental primary afferent neurons: implication for tooth pain. J Biol Chem. 2006 Jun 23;281(25):17304-11.
31. Li J, Koo NY, Cho IH, Kwon TH, Choi SY, Lee SJ, Oh SB, Kim JS, Park K. Expression of sodium bicarbonate cotransporter and its role in pHi regulation in guinea pig salivary glands.
Am J Physiol Gastrointest Liver Physiol. 2006 Dec;291(6):G1031-40.
32. Lee H, Choi S-Y, Oh SB, Park K, Kim JS, Lee SJ. Damaged neuronal cells induce inflammatory gene expression in Schwann cells. Int. J. Oral Biol., 31(3):87-92. (Sep. 30.)
33. Choi SY, Li J, Jo SH, Lee SJ, Oh SB, Kim JS, Lee JH, Park K. Desipramine inhibits na+/h+ exchanger in human submandibular cells. J Dent Res. 2006 Sep;85(9):839-43.
34. Li J, Lee S, Choi SY, Lee SJ, Oh SB, Lee JH, Chung SC, Kim JS, Lee JH, Park K. Effects of pilocarpine on the secretory acinar cells in human submandibular glands.
Life Sci. 2006 Nov 25;79(26):2441-7.
35. Park CK, Li HY, Yeon KY, Jung SJ, Choi SY, Lee SJ, Lee S, Park K, Kim JS, Oh SB. Eugenol inhibits sodium currents in dental afferent neurons. J Dent Res. 2006 Oct;85(10):900-4.
36. Lee H, Jo EK, Choi SY, Oh SB, Park K, Soo Kim J, Lee SJ. Necrotic neuronal cells induce inflammatory Schwann cell activation via TLR2 and TLR3: Implication in Wallerian degeneration. Biochem Biophys Res Commun. 2006 Nov 24;350(3):742-7.
37. Yang CS, Lee JS, Song CH, Hur GM, Lee SJ, Tanaka S, Akira S, Paik TH, Jo EK.Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2.
Cell Microbiol. 2007, Feb. 9, 9(2) : 382-396.
38. Lee H, Park C, Cho IH, Kim HY, Jo EK, Lee S, Kho HS, Choi SY, Oh SB, Park K, Kim JS, Lee SJ. Double-stranded RNA Induces iNOS Gene Expression in Schwann Cells, Sensory Neuronal Death, and Peripheral Nerve Demyelination. Glia. 2007, 55:712-722.
39. Kim D, Kim MA, Cho IH, Kim MS, Lee S, Jo EK, Choi SY, Park K, Kim JS, Akira S, Na HS, Oh SB, Lee SJ. A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity. J Biol Chem. 2007, May 18;282(20):14975-14983.
40. Yoshida H, Imaizumi T, Lee SJ, Tanji K, Sakaki H, Matsumiya T, Ishikawa A, Taima K, Yuzawa E, Mori F, Wakabayashi K, Kimura H, Satoh K. Retinoic acid-inducible gene-I mediates RANTES/CCL5 expression in U373MG human astrocytoma cells stimulated with double-stranded RNA. Neurosci. Res. 2007, 58:199-206.
41. Ko HG, Lee SJ, Son H, Kaang BK. Null effect of antidepressants on the astrocytes-mediated proliferation of hippocampal progenitor cells in vitro. Mol. Pain 2007 Jun 15;3(1):16.
42. Li HY, Park CK, Jung SJ, Choi SY, Lee SJ, Park K, Kim JS, Oh SB. Eugenol inhibits K+ currents in trigeminal ganglion neurons. J Dent Res. 2007 Sep;86(9):898-902.
43. Yang CS, Lee HM, Lee JY, Kim JA, Lee SJ, Shin DM, Lee YH, Lee DS, El-Benna J, Jo EK. Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia. J. Neuroinflammation. 2007 Nov 26;4:27.
44. Park C, Cho I-H, Kim D, Jo E-K, Choi S-Y, Oh SB, Park K, Kim JS, Lee SJ. Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury. Neuroscience Lett. 2008 Jan 31;431(2):123-8.
45. Yang CS, Shin DM, Lee HM, Son JW, Lee SJ, Akira S, Gougerot-Pocidalo MA, El-Benna J, Ichijo H, Jo EK. ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling. Cell Microbiol. 2008 Mar;10(3):741-54.
46. Koo NY, Li J, Hwang SM, Choi SY, Lee SJ, Oh SB, Kim JS, Lee EB, Song YW, Park K. Functional epitope of muscarinic type 3 receptor which interacts with autoantibodies from Sjogren’s syndrome patients. Rheumatology (Oxford). 2008 Jun;47(6):828-33.
47. Shin DM, Yang CS, Yuk JM, Lee JY, Kim KH, Shin SJ, Takahara K, Lee SJ, Jo EK. Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1. Cell Microbiol. 2008 Aug; 10(8): 1608-1621.
48. Shin DM, Yang CS, Lee JY, Lee SJ, Choi HH, Lee HM, Yuk JM, Harding CV, Jo EK. Mycobacterium tuberculosis lipoprotein-induced association of TLR2 with protein kinase C xi in lipid rafts contributes to reactive oxygen species-dependent inflammatory signaling in macrophages.Cell Microbiol. 2008 Sep. 10(9):1893-1905.
49. Cho I-H, Hong J, Suh EC, Lee H, Lee S, Jo E-K, Lee K, Karin M and Lee SJ, Role of microglial IKK in kainic acid-induced hippocampal neuronal cell death. Brain. 2008. Nov. 131:3019-3033.
50. Lee H, Park K, Kim JS, Lee SJ. Vasoactive intestinal peptide inhibits TLR3-induced nitric oxide production in Schwann cells and subsequent sensory neuronal death. J. Neurosci. Res. 2009. 87: 171-178.
51. Kim D, Lee S, Lee SJ. Toll-like receptors in peripheral nerve injury and neuropathic pain. Current Topics in Microbiology and Immunology. 2009. 336:169-186.
52. Yang CS, Yuk JM, Shin DM, Kang J, Lee SJ, Jo EK. Secretory phospholipase A2 plays an essential role in microglial inflammatory responses to Mycobacterium tuberculosis. Glia. 2009 Aug 1;57(10):1091-103.
53. Kim JH, Park SH, Moon YW, Hwang S, Kim D, Jo SH, Oh SB, Kim JS, Jahng JW, Lee JH, Lee SJ, Choi SY, Park K. Histamine H1 receptor induces cytosolic calcium increase and aquaporin translocation in human salivary gland cells. J Pharmacol Exp Ther. 2009 Aug;330(2):403-12.
54. Hwang SM, Li J, Koo NY, Choi SY, Lee SJ, Oh SB, Castro R, Kim JS, Park K. Role of purinergic receptor in alpha fodrin degradation in Par C5 cells. J Dent Res. 2009 Oct;88(10):927-32.
55. Park C, Lee S, Park K, Kim JS, Lee SJ. Synergy of TLR2 and H1R on Cox-2 expression in pulp cells. J. Dent. Res. 2010, 89(2): 180-185.
56. Kang SS, Han KS, Ku BM, Lee YK, Hong J, Shin HY, Almonte AG, Woo DH, Brat DJ, Hwang EM, Yoo SH, Chung CK, Park SH, Paek SH, Roh EJ, Lee SJ, Park JY, Traynelis SF, Lee CJ. Caffeine-Mediated Inhibition of Calcium Release Channel Inositol 1,4,5-Trisphosphate Receptor Subtype 3 Blocks Glioblastoma Invasion and Extends Survival. Cancer Res. 2010, 70(3), 1173-83.
57. Kim D, Cho SH, Kim JS, Jo SH, Lee SJ, Kim KT, Choi SY. Human astrocytic bradykinin B(2) receptor modulates zymosan-induced cytokine expression in 1321N1 cells. Peptides. 2010 Jan;31(1):101-7.
58. Park JS, Yoo SB, Kim JY, Lee SJ, Oh SB, Kim JS, Lee JH, Park K, Jahng JW, Choi SY. Effects of saccharin intake on hippocampal and cortical plasticity in juvenile and adolescent rats. Korean J Physiol Pharmacol. 2010 Apr;14(2):113-8.
59. Li J, Jeong MY, Bae JH, Shin YH, Jin M, Hang SM, Lee JC, Lee SJ, Park K. Toll-like receptor 3-mediated induction of chemokines in salivary epithelial cells. Korean J Physiol Pharmacol. 2010 Aug; 14: 235-240.
60. Kim D, Yoo B, Jo E-K, Han S-K, Simon MI, Lee SJ. Nox2-derived ROS in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. PNAS. 2010, 107 (33): 14851-14856.
61. Hong J, CHO IH, Suh EC, Kwak KI, Seo JS, Choi SY Park HW, Jo EK, Lee S, Lee K, Lee SJ. Microglial Toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death. J Biol Chem. 2010 Dec 10;285(50):39447-57.
62. Oh GS, Kim HJ, Choi JH, Shen A, Kim CH, Kim SJ, Shin SR, Hong SH, Kim Y, Park C, Lee SJ, Akira S, Park R, So HS. Activation of lipopolysaccharide-TLR4 signaling accelerates the ototoxic potential of cisplatin in mice. J Immunol. 2011 Jan 15;186(2):1140-50.
63. Kim SJ, Park GH, Kim D, Lee J, Min H, Wall E, Lee CJ, Simon MI, Lee SJ (co-correspondence), Han S-K. Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in TRPV1-expressing neurons. 2011, PNAS, 108 (8): 3371-6.
64. Kyung Jin Jung, Dong Woon Kim, Ha Na Lee, Mi Ok Lee, Sung Joong Lee, Jeong-Hwan Che, Yong Ho Lee, Byeong-Cheol Kang. The role of Endothelin receptor A during myelination ofdeveloping oligodendrocytes, Journal of Korean Medical Science, 2011, January; 26(1): 92–99
65. Kang J, Jiang MH, Lee H, Jo EK, Karin M, Yune TY, Lee SJ. IKK beta-mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury. 2011, Eur. J. Immunol. 41: 1266-1277.
66. Kim D, You B, Lim H, and Lee SJ. Toll-like receptor 2 contributes to chemokine gene expression and macrophage infiltration in the dorsal root ganglia after peripheral nerve injury. 2011, Mol. Pain, 7:74-83.
67. Lee J, Kim T, Hong J, Woo J, Min H, Hwang E, Lee SJ (co-correspondence), Lee CJ. Imiquimod enhances excitability of dorsal root ganglion neurons by inhibiting background (K2P) and voltage-gated (Kv1.1 and Kv1.2) potassium channels. Mol. Pain. 2012 Jan 11;8(1):2.
68. Lee HK, Park DW, Bae JH, Kim HJ, Shin DG, Park JS, Lee JG, Lee SJ, Bae YS, Baek SH. RGS2 is a negative regulator of STAT3-mediated Nox1 expression. Cell Signal. 2012 Mar;24(3):803-9.
69. Jung BK, Pyo KH, Shin KY, Hwang YS, Lim H, Lee SJ, Moon JH, Lee SH, Suh YH, Chai JY, Shin EH. Toxoplasma gondii infection in the brain inhibits neuronal degeneration and learning and memory impairments in a murine model of Alzheimer’s disease. PLoS One. 2012;7(3):e33312.
70. Hong J, Kim BK, Lim H, Lee S, Lee SJ. Identification and characterization of triamcinolone acetonide, a microglial-activation inhibitor. Immunopharmacol Immunotoxicol. 2012 34(6): 912-918.
71. Seo J, Hong J, Lee SJ, Choi SY c-Jun N-terminal phosphorylation is essential for hippocampal synaptic plasticity. Neurosci Lett. 2012 Nov 30;531(1):14-9.
72. Lee HM, Kang J, Lee SJ, Jo EK. Microglial activation of the NLRP3 inflammasome by the priming signals derived from macrophages infected with mycobacteria. Glia. 2013, 61(3):441-52.
73. Lim HS, Kim D, Lee SJ. Toll-like receptor 2 mediates peripheral nerve injury-induced NADPH oxidase 2 expression in spinal cord microglia. J. Biol. Chem. 2013 Mar 15;288(11):7572-9.
74. Kim C, Ho DH, Suk JE, You S, Michael S, Kang J, Lee SJ, Masliah E, Hwang D, Lee HJ, Lee SJ. Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nat Commun. 2013 Mar 5;4:1562.
75. Lee H, Lee S, Cho IH, Lee SJ. Toll-like receptors: sensor molecules for detecting damage to the nervous system. Curr Protein Pept Sci. 2013. 14(1):33-42 (Feb)
76. Yang CS, Kim JJ, Lee SJ, Hwang JH, Lee CH, Lee MS, Jo EK. TLR3-Triggered Reactive Oxygen Species Contribute to Inflammatory Responses by Activating Signal Transducer and Activator of Transcription-1. J Immunol. 2013 Jun 15;190(12):6368-77
77. Suh EC, Jung YJ, Kim YA, Park EM, Lee SJ, Lee KE. Knockout of Toll-like receptor 2 attenuates Aβ25-35-induced neurotoxicity in organotypic hippocampal slice cultures. Neurochem Int. 2013 Dec;63(8):818-25.
78. Choi JY, Cui Y, Kang YM, Kim JH, Lee SJ, Kim BG. Role of toll-like receptor 2 in ischemic demyelination and oligodendrocyte death. Neurobiol Aging. 2014 Feb 5. pii: S0197-4580(14)00168-7.
79. Hayward JH, Lee SJ. A Decade of Research on TLR2 Discovering Its Pivotal Role in Glial Activation and Neuroinflammation in Neurodegenerative Diseases. Exp Neurobiol. 2014 Jun;23(2):138-47.
80. Hwang H, Min H, Kim D, Yu SW, Jung SJ, Choi SY, Lee SJ. Imiquimod induces a Toll-like receptor 7-independent increase in intracellular calcium via IP3 receptor activation. Biochem Biophys Res Commun. 2014 Jul 18; 450(1):875-9.
81. Lee K, Kim SJ, Kim D, Jo SH, Lee SJ, Choi SY. Prostaglandin modulates TLR3-induced cytokine expression in human astroglioma cells. Brain Res. 2014 Jul 8
82. Min H, Lee H, Lim H, Jang YH, Chung SJ, Lee CJ, Lee SJ.TLR4 enhances histamine-mediated pruritus by potentiating TRPV1 activity. Mol Brain. 2014 Aug 21;7(1):59.
83. Lee SJ. Molecular mechanisms of itch and pain: An overview. Itch & Pain, 2015, 2 (1). (DOI: http://dx.doi.org/10.14800/ip.554)
84. Min H, Hong J, Cho I-H, Jang YH, Lee H, Kim D, Yu S-W, Lee S, Lee SJ, TLR2-induced astrocyte MMP9 activation compromises the blood brain barrier and exacerbates intracerebral hemorrhage animal models. 2015, Mol. Brain, 8:23.
85. Yoon H, Jang YH, Kim SJ, Lee SJ (co-correspondence), Kim SK. Toll-like Receptor 2 is Dispensable for an Immediate-early Microglial Reaction to Two-photon Laser-induced Cortical Injury In vivo.
Korean J Physiol Pharmacol. 2015 Sep;19(5):461-5.
86. Shin WH, Jeon MT, Leem E, Won SY, Jeong KH, Park SJ, McLean C, Lee SJ, Jin BK, Jung UJ, Kim SR. Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson’s disease. Sci Rep. 2015 Oct 6;5:14764
87. Lee MJ, Jang M, Choi J, Lee G, Min HJ, Chung WS, Kim JI, Jee Y, Chae Y, Kim SH, Lee SJ, Cho IH. Bee Venom Acupuncture Alleviates Experimental Autoimmune Encephalomyelitis by Upregulating Regulatory T Cells and Suppressing Th1 and Th17 Responses. Mol Neurobiol. 2016 Apr;53(3):1419-45
88. Min H, Jang YH, Cho IH, Yu SW, Lee SJ. Alternatively activated brain-infiltrating macrophages facilitate recovery from collagenase-induced intracerebral hemorrhage. Mol Brain. 2016 Apr 19;9:42.
89. Lee MJ, Bing SJ, Choi J, Jang M, Lee G, Lee H, Chang BS, Jee Y, Lee SJ (co-correspondence), Cho IH. IKKβ-mediated inflammatory myeloid cell activation exacerbates experimental autoimmune encephalomyelitis by potentiating Th1/Th17 cell activation and compromising blood brain barrier. Mol. Neurodegener. 2016 Jul 22;11(1):54.
90. Yi MH, Zhang E, Kim JJ, Baek H, Shin N, Kim S, Kim SR, Kim HR, Lee SJ, Park JB, Kim Y, Kwon OY, Lee YH, Oh SH, Kim DW. CD200R/Foxp3-mediated signalling regulates microglial activation. Sci Rep. 2016 Oct 12;6:34901.
91. Lee H, Baek J, Min H, Cho IH, Yu SW, Lee SJ. Toll-Like Receptor 3 Contributes to Wallerian Degeneration after Peripheral Nerve Injury. Neuroimmunomodulation. 2016, 23(4), 209-216
92. Lim H. Gwon M. Lee SJ. Toll-like receptor 2 signaling induces interferon regulatory factor 8 expression in spinal cord microglia after peripheral nerve injury. Itch & Pain, 2016, 3 (e): 1457
93. Cho WH, Barcelon E, Lee SJ. Optogenetic Glia Manipulation: Possibilities and Future Prospects. Exp. Neurobiol. 2016 Oct;25(5):197-204.
94. Kim H, Chun Y, Che L, Kim J, Lee S, Lee S. The new obesity-associated protein, neuronal growth regulator 1 (NEGR1), is implicated in Niemann-Pick disease Type C (NPC2)-mediated cholesterol trafficking. Biochem Biophys Res Commun. 2017 Jan 22; 482(4):1367-1374
95. Shin WG, Park BJ, Lee SJ, Kim JG. Infection of human intestinal epithelial cells by invasive bacteria activates NF-κB and increases ICAM-1 expression through NOD1. Korean J Intern Med. 2017 (in press)
96. Kim H, Choi B, Lim H, Min H, Oh JH, Choi S, Cho JG, Park JS, Lee SJ. Polyamidoamine dendrimer-conjugated triamcinolone acetonide attenuates nerve injury-induced spinal cord microglia activation and mechanical allodynia. Mol Pain. 2017 Jan 13; 13:1-11
97. Min H, Choi B, Jang YH, Cho IH, Lee SJ. Heme molecule functions as an endogenous agonist of astrocyte TLR2 to contribute to secondary brain damage after intracerebral hemorrhage. Mol Brain. 2017 Jun 24;10(1):27
98. Lim H, Lee H, Noh K, Lee SJ. IKK/NF-κB-dependent satellite glia activation induces spinal cord microglia activation and neuropathic pain after nerve injury. Pain. 2017 Sep; 158(9):1666-1677
99. Nho B, Lee J, Lee J, Ko KR, Lee SJ, Kim S. Effective control of neuropathic pain by transient expression of hepatocyte growth factor in a mouse chronic constriction injury model. FASEB J. 2018 Sep;32(9):5119-5131
100. Kim D, Yoo JM, Hwang H, Lee J, Lee SH, Yun SP, Park MJ, Lee M, Choi S, Kwon SH, Lee S, Kwon SH, Kim S, Park YJ, Kinoshita M, Lee YH, Shin S, Paik SR, Lee SJ, Lee S, Hong BH, Ko HS. Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease. Nat Nanotechnol. 2018 Sep;13(9):812-818
101. Min H, Cho WH, Lee H, Choi B, Lee HK, Kim YJ, Joo Y, Jung SJ, Choi SY, Lee S, Lee SJ. Association of TRPV1 and TLR4 through the TIR domain potentiates TRPV1 activity by blocking activation-induced desensitization. Mol Pain. 2018 Oct 25:1744806918812636. doi: 10.1177/1744806918812636.
102. Lee JW, Nam H, Kim LE, Jeon Y, Min H, Ha S, Lee Y, Kim SY, Lee SJ, Kim EK, Yu SW. TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia. Autophagy. 2019 May;15(5):753-770.
103. Noh K, Lee H, Choi T-Y, Joo Y, Kim S-J, Kim H, Kim JY, Jahng JW, Lee S, Choi S-Y, Lee SJ. Negr1 controls adult hippocampal neurogenesis and affective behaviors Mol. Psychiatry. 2019 Aug;24(8):1189-1205.
104. Jang M, Choi JH, Chang Y, Lee SJ, Nah SY, Cho IH. Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for Huntington’s disease: Activation of the Nrf2 pathway through lysophosphatidic acid receptors. Brain Behav Immun. 2019 Mar 7. pii: S0889-1591(18)30392-1. doi: 10.1016/j.bbi.2019.03.001
105. Barcelon EE, Cho WH, Jun SB, Lee SJ. Brain Microglial Activation in Chronic Pain-Associated Affective Disorder. Front Neurosci. 2019 Mar 15;13:213. doi: 10.3389/fnins.2019.00213.
106. Noh K, Lee H, Choi TY, Joo Y, Kim SJ, Kim H, Kim JY, Jahng JW, Lee S, Choi SY, Lee SJ. Negr1 regulates hippocampal Lcn2 expression and affective behaviour via interaction with LIF receptor. Mol. Psychiatry. 2019 Aug;24(8):1095.
107. Joo Y, Kim H, Lee SJ, Lee S.Neuronal growth regulator 1-deficient mice show increased adiposity and decreased muscle mass. Int J Obes (Lond). 2019 Sep;43(9):1769-1782.
108. Choi B, Soh M, Manandhar Y, Kim D, Han SI, Baik S, Shin K, Koo S, Kwon HJ, Ko G, Oh J, Hwang H, Hyeon T, Lee SJ. Highly selective microglial uptake of ceria-zirconia nanoparticles for enhanced analgesic treatment of neuropathic pain. Nanoscale. 2019 Oct 25;11(41):19437-19447.
109. Won S, Park K, Lim H, Lee SJ. Sexual dimorphism in cognitive disorders in a murine model of neuropathic pain. Behav Brain Funct. 2020 Jan 4;16(1):1.
110 Lim H, Lee J, You B, Oh JH, Mok HJ, Kim YS, Yoon BE, Kim BG, Back SK, Park JS, Kim KP, Schnaar RL, Lee SJ. GT1b functions as a novel endogenous agonist of toll-like receptor 2 inducing neuropathic pain. EMBO J. 2020 Feb 6:e102214.
111. Noh K, Park JC, Han JS, Lee SJ. From Bound Cells Comes a Sound Mind: The Role of Neuronal Growth Regulator 1 in Psychiatric Disorders. Exp Neurobiol. 2020 Feb 29;29(1):1-10.
112. Park K, Lee SJ. Deciphering the star codings: astrocyte manipulation alters mouse behavior. Exp Mol Med. 2020 Jul 15;52(7):1028-1038.
113. Jo YR, Kim HR, Jang SY, Go H, Song MY, Park DK, Oh Y, Jo J, Shin YK, Lee SJ, Cheon SM, Lee HK, Lee KE, Kim YH, Park HT. Potential neuron-autonomous Purkinje cell degeneration by 2′,3′-cyclic nucleotide 3′-phosphodiesterase promoter/Cre-mediated autophagy impairments. FASEB J. 2021 Jan;35(1):e21225.
(대한민국특허) 신경병증성 통증을 억제하기 위한 TLR2 유전자 및 이의 폴리펩티드, 및 이를 이용한 통증 억제 방법 (등록번호:10-0814348; 등록일: 2008. 03. 11)
(대한민국특허) 설포라판 및 이의 유사체를 포함하는 통증치료제 (등록번호:10-1188945; 등록일: 2012. 09. 28)
(대한민국특허) 가려움증을 유발하지 않는 항바이러스 물질 스크리닝 방법
(등록번호:10-1229715; 등록일: 2013. 01. 29)
(대한민국특허) 설포라판 및 이의 유사체를 포함하는 건강 기능 식품 조성물
(등록번호:10-1243430; 등록일: 2013. 03. 07)
(대한민국특허) 신경병증성 통증치료제의 스크리닝 방법(등록번호:10-1626058;등록일: 2016. 05. 25)
(대한민국특허) 덴드리머를 포함하는 신경교세포 약물 전달체, 및 이를 이용한 신경병증성 통증 예방 또는 치료용 조성물 (등록번호:10-1722743; 등록일: 2017. 03. 28)
Soojin Lee and Sung Joong Lee, Toll-like receptors: sensor molecules for infection and tissue damage in the nervous system. Ch 5. Neuroimmunology Research Perspective, 2007, Nova Science Publishers Inc.
Kim D, Lee S, Lee SJ. Toll-like receptors in peripheral nerve injury and neuropathic pain. Chapter 10, Current Topics in Microbiology and Immunology. 2009.Springer Science
Lee H, Lee S, Cho IH, Lee SJ. Toll-like receptors: sensor molecules for detecting damage to the nervous system. Curr Protein Pept Sci. 2013 Bentham Science
S. J. Lee. Toll-like receptors and Neuroinflammation. Chapter 9. In Neuro-glia interactions in neuroinflammation. 2013. Springer Science
