1985.03-1991.02
D.D.S., 서울대학교 치과대학 (치의학 학사)
1992.09-1999.08
Ph.D., 미국 University of Pittsburgh School of Medicine (전공: 신경과학)
박사학위 논문명 : The effects of stress on tyrosine hydroxylase gene transcription rate in the locus coeruleus (지도교수: Michael J. Zigmond, Ph.D.)
2003.08-현재
전임강사, 조교수, 부교수, 교수, 서울대학교 치의학대학원
2001.07-2003.07
박사후 연구원, 미국 Skirball Inst. of Biomolecular Medicine, New York University School of Medicine
2000.09-2001.11
박사후 연구원, 미국 College of Physicians & Surgeons, Columbia University
1999.08-2000.07
박사후 연구원, 미국 Harvard Medical School/Dana-Farber Cancer Institute
1995.03-1998.03
강의/실습 조교, Department of Molecular Genetics & Biochemistry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
1993.09-1999.07
연구 조교, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
2017.03-현재
주임교수, 서울대 치의학대학원 구강해부학교실
2014.11-현재
의과대학 협동과정 줄기세포생물학전공 겸무 교수
2013.06-현재
치의학대학원 치의학과 겸무 교수
2013.04-현재
자연과학대학 협동과정 유전공학전공 겸무 교수
2013.03-현재
치학연구소 겸무 연구원
2006.03-현재
의학연구원 겸무 연구원
2005.03-현재
치과대학 치의학과 겸무 교수
2004.11-현재
자연과학대학 협동과정 뇌과학전공 겸무 교수
2004.09-현재
치과병원 겸무 교수
2003.09-2004.08
특수법인 서울대학교병원 겸무 교수
2017-현재
Korean Society for Stem Cell Research 대의원, 편집간사
2006-현재
Korean Society for Stem Cell Research 이사
2006-현재
International Society for Stem Cell Research 회원
2003-현재
The Korean Academy of Oral Anatomy 이사
2003-현재
Korean Society for Molecular and Cellular Biology 회원
2003-현재
Women’s Bioscience Forum 회원
2003-현재
The Korean Society for Brain and Neural Science 회원
1997-현재
Society for Neuroscience 회원
간 성체줄기세포에서 신경세포/교세포로의 리프로그래밍 연구
인간 성체줄기세포 분화를 이용한 신경정신질환의 질환 모델링 연구
퇴행성 신경계 질환의 치료를 위한 줄기세포 치료제 개발
신경재생 기전 연구
미세유체칩을 이용한 줄기세포 분리
2012
서울대 치의학대학원 우수 강의상
2010
서울대 치의학대학원 우수 강의상
2001-2003
Postdoctoral Fellowship in Pharmacology-Morphology including Cell Biology at the Pharmaceutical Research and Manufacturers of America Foundation
1998
Association of Korean Neuroscientist Outstanding Researcher Award
1997
The University of Pittsburgh Center for Neuroscience Travel Award for the Computer-Assisted Neurocartography Workshop, Drexel University, Philadelphia, PA
1995
Pittsburgh Cancer Institute Outstanding Researcher Award
1. Hwang M, Song S, Chang MS*, Koh SH*. Glia-Like Cells from Human Mesenchymal Stem Cells Protect Neural Stem Cells in an in vitro Model of Alzheimer’s Disease by Reducing NLRP-3 Inflammasome. Dementia and Neurocognitive Disorders. 19(4):e19 (pISSN: 1738-1495, eISSN 2384-0757) 2021.01. *Co-corresponding author
2. Lee J, Chang MS. Role of DARPP-32 in the Proliferation and Survival of Human Neural Stem Cells. The Korean Journal of Oral Anatomy. 41(1)97-108. (ISSN : 1225–6803) 2020.12.31.
3. Son JW, Park J, Kim YE, Ha J, Park DW, Chang MS*, Koh SH*. Glia-like cells from late-passage human MSCs protect against ischemic stroke through IGFBP-4. Mol. Neurobiol. 56:7617-7630, 2019.05.12. *Co-corresponding author
https://link.springer.com/article/10.1007%2Fs12035-019-1629-8
4. Park HW, Oh S, Lee KH, Lee BH, Chang MS. Olig2-expressing Mesenchymal Stem Cells Enhance Functional Recovery after Contusive Spinal Cord Injury. Int. J. Stem Cells. 11(2):177–186, 2018.10.
https://doi.org/10.15283/ijsc18071
5. Jeon HJ, Park J, Shin JH, Chang MS. Insulin-like growth factor binding protein-6 released from human mesenchymal stem cells confers neuronal protection through IGF-1R-mediated signaling. Int. J. Mol. Med. 40(6):1860-1868, 2017.12.
https://www.spandidos-publications.com/10.3892/ijmm.2017.3173
6. Park J, Lee N, Lee J, Choe EK, Kim MK, Lee J, Byun MS, Chon MW, Kim SW, C. Justin Lee, Kim JH, Kwon JS, Chang MS. Small molecule-based lineage switch of human adipose-derived stem cells into neural stem cells and functional GABAergic neurons. Scientific Reports. 7(1):10166, 2017.08.
https://www.nature.com/articles/s41598-017-10394-y
7. Shin JH, Jeon HJ, Park JH, Chang MS. Epigallocatechin-3-gallate prevents oxidative stress-induced cellular senescence in human mesenchymal stem cells via Nrf2. Int. J. Mol. Med. 38(4):1075-1082, 2016.10.
https://www.spandidos-publications.com/10.3892/ijmm.2016.2694
8. Park HW, Jeon HJ, Chang MS. Vascular endothelial growth factor enhances axonal outgrowth in organotypic spinal cord slices via vascular endothelial growth factor receptor 1 and 2. Tissue Engineering Regen. Med. 13(5):601-609, 2016.10.
http://link.springer.com/article/10.1007/s13770-016-0051-9
9. Chang MS, Yoo JH, Woo DH and Chun MS. Efficient detection of Escherichia coli O157:H7 using a reusable microfluidic chip embedded with antimicrobial peptide-labeled beads. Analyst. 140(23):7997-8006,2015.12.07.
http://pubs.rsc.org/en/Content/ArticleLanding/2015/AN/C5AN01307K#!divAbstract
10. Jung H, Chun MS*, Chang MS*. Sorting of human mesenchymal stem cells by applying optimally designed microfluidic chip filtration. Analyst. 140(4):1265-1274, 2015.02.21. *Co-corresponding author
http://pubs.rsc.org/en/Content/ArticleLanding/2015/AN/C4AN01430H#!divAbstract
11. Jung H, Shin JH, Park YS, and Chang MS. Ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein regulates neuroblastoma cell proliferation through p21. Molecules and Cells. 37(12):881-887, 2014. 12. 31.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275705/
12. Yoo JH, Woo DH, Chang MS*, Chun MS*. Microfluidic based biosensing for Escherichia coli detection by embedding antimicrobial peptide-labeled beads. Sensors and Actuators B 191:211– 218, 2014.02. * Co-corresponding author
http://www.sciencedirect.com/science/article/pii/S0925400513011581
13. Lee EJ, Park HW, Jeon HJ, Kim HS*, Chang MS*. Potentiated therapeutic angiogenesis by primed human mesenchymal stem cells in a mouse model of hindlimb ischemia. Regenerative Medicine. 8(3):283-293, 2013.05.08. * Co-corresponding author
http://www.futuremedicine.com/doi/abs/10.2217/rme.13.17
14. Yang ST, Kim HK, Lim YS, Chang MS, Lee SP, Park YS. A three dimensional observation of palatal vault growth in children using mixed effect analysis: a 9 year longitudinal study. European J. Orthodontics 35:832–840, 2013.
https://academic.oup.com/ejo/article-lookup/doi/10.1093/ejo/cjs104
15. Park HW, Cho JS, Park CK, Jung SJ, Park CH, Lee SJ, Oh SB, Park YS, Chang MS. Directed induction of functional motor neuron-like cells from genetically engineered human mesenchymal stem cells. PLoS ONE 7(4): e35244, 2012.04.05.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035244
16. Park YS, Chang MS, Lee SP. Three dimensional topography of the gingival line of young adult maxillary teeth: curve averaging using reverse-engineering methods. Int. J. Oral & Maxillofacial Implants 26(6):1217-1224, 2011.
http://web.a.ebscohost.com/ehost/detail/detail?vid=2&sid=06279920-5b5a-4377-a592439e320d7848%40sessionmgr4006&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#AN=69533171&db=ddh
17. Yoon EH, Lee KJ, Kim YS, Chang MS, Lee SH, Park CH. Retinoid X receptor acts as a negative regulator in Nurr1-induced dopaminergic differentiation in rat neural precursor cells. Neuroreport 21(18):1162-1166, 2010.12.
http://ovidsp.tx.ovid.com/sp3.26.1a/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&AN=00001756-201012290-00006&NEWS=N&CSC=Y&CHANNEL=PubMed
18. Kim IS, Paik KS, Chang MS, Lee SP. The effect of differential modulation of the N-methyl-D-aspartate receptor on growth and intracellular calcium ion concentration in normal human oral keratinocytes. Tissue Engineering Regen. Med. 7(5):489-500, 2010.10.
http://s-space.snu.ac.kr/handle/10371/81335
19. Park HJ, Park HW, Lee SJ, Arevalo JC, Park YS, Lee SP, Paik KS, Chao MV, Chang MS. Ankyrin repeat-rich membrane spanning/Kidins220 protein interacts with mammalian Septin 5. Mol. Cells 30(2):143-148,2010.08.
http://www.molcells.org/journal/view.html?year=2010&volume=30&number=2&spage=143
20. Park HW, Lim MJ, Jung H, Lee SP, Paik KS, Chang MS. Human mesenchymal stem cell-derived Schwann cell-like cells exhibit neurotrophic effects, via distinct growth factor production, in a model of spinal cord injury. Glia. 58(9):1118-1132, 2010.07.
http://onlinelibrary.wiley.com/doi/10.1002/glia.20992/abstract;jsessionid=B6DB9714660DFDD2E5770A8096B10FFD.f02t02
21. Oh S, Park HW, Cho JS, Jung H, Lee SP, Paik KS, Chang MS. Induction of a neuronal phenotype from human bone marrow-derived mesenchymal stem cells. Int. J. Oral Biol. 34(4):177-183, 2009.12.
http://s-space.snu.ac.kr/handle/10371/73525
22. Cho JS, Park HW, Park SK, Roh S, Kang SK, Paik KS, Chang MS. Transplantation of mesenchymal stem cells enhances axonal outgrowth and cell survival in an organotypic spinal cord slice culture. Neurosci. Lett. 454(1):43-48, 2009.04.
http://www.sciencedirect.com/science/article/pii/S030439400900202X?via%3Dihub
23. Lee Y, Yu JH, Cho JS, Park HJ, Lee SP, Paik KS, Chang MS. Interaction between the p75 neurotrophin receptor and a novel adaptor protein. Int. J. Oral Biol. 33(2):71-76, 2008.06.
http://s-space.snu.ac.kr/handle/10371/69796
24. Sauvageot C, Dahia PL, Lipan O, Park JK, Chang MS, Alberta JA, Stiles CD. Distinct temporal genetic signatures of neurogenic and gliogenic cues in cortical stem cell cultures. J. Neurobiol. 62(1):121-133, 2005.01.
http://onlinelibrary.wiley.com/doi/10.1002/neu.20072/abstract
25. Chang MS, Arevalo JC, Chao MV. Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein. J. Neurosci. Res. 78(2):186-192, 2004.10.
http://onlinelibrary.wiley.com/doi/10.1002/jnr.20262/abstract
26. Chang MS, Sved AF, Zigmond MJ, and Austin MC. Increased transcription of the tyrosine hydroxylase gene in individual locus coeruleus neurons following footshock stress. Neuroscience. 101(1): 131-139,2000.10.
http://www.sciencedirect.com/science/article/pii/S0306452200003523?via%3Dihub
27. Chang MS, Hahn MK., Sved AF, Zigmond MJ, Austin MC and Sherman TG. Analysis of tyrosine hydroxylase gene transcription using an intron specific probe. J. Neuroscience Methods. 94(2): 177-185, 2000.01.
http://www.sciencedirect.com/science/article/pii/S0165027099001375?via%3Dihub
1. Composition and method for differentiation of neural stem cells, neurons and GABAergic neurons from mesenchymal stem cells, United States, No. 10,280,399, 2019.05.07.
2. Neuronal regeneration material screening method by ex vivo model, United States, No. 7,947,435, 2011.05.24.
3. Differentiation method of adipose-derived mesenchymal stem cells into neural stem cells, neural cells, and GABAergic neural cells, Republic of Korea, No. 10-1870240-0000, 2018.06.18.
4. A composition for treating disease caused by neuronal insult comprising Schwann cell-like cells that secreting high amount of growth factors as active ingredients, Republic of Korea, No. 10-1147412-0000, 2012.05.11.
5. Method for inducing differentiation of human mesenchymal stem cells into motor neurons, Republic ofKorea, No. 10-0973324-0000, 2010.07.26.
6. Neuronal regeneration material screening method by ex vivo model, Republic of Korea, No. 10-0930221-0000, 2009.11.30.
7. Method of inducing differentiation of mesenchymal stem cells into neurons, Republic of Korea, No. 10-0890992-0000, 2009.03.23.
